PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation (Q33569771)

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English	PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

title

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation (English)

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

main subject

hypoxia

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T cell activation

1 reference

based on heuristic

inferred from title

author

Saoussen Karray

object named as

Saoussen Karray

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5

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Meriem Hasmim

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Meriem Hasmim

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4

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Salem Chouaib

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8

object named as

Salem Chouaib

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

author name string

Muhammad Zaeem Noman

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1

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

Giacomo Desantis

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2

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

Bassam Janji

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3

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

Philippe Dessen

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6

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

Vincenzo Bronte

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7

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

language of work or name

English

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publication date

28 April 2014

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

published in

Journal of Experimental Medicine

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

volume

211

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

issue

5

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

page(s)

781-790

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Europe PubMed Central

PubMed publication ID

24778419

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28 July 2017

cites work

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

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Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

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Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

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Regulatory T cells stimulate B7-H1 expression in myeloid-derived suppressor cells in ret melanomas

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Oxygen sensing, homeostasis, and disease

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21 June 2018

Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80

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21 June 2018

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

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Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

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21 June 2018

Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation

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Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia.

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The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis.

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PD-1 and PD-1 ligands: from discovery to clinical application

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Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).

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The B7 family revisited

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21 June 2018

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

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PubMed Central

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Immortalized myeloid suppressor cells trigger apoptosis in antigen-activated T lymphocytes.

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21 June 2018

Identifiers

DOI

10.1084/JEM.20131916

1 reference

stated in

Europe PubMed Central

PubMed publication ID

24778419

retrieved

28 July 2017

PMC publication ID

4010891

1 reference

stated in

Europe PubMed Central

PubMed publication ID

24778419

retrieved

28 July 2017

PubMed publication ID

24778419

1 reference

stated in

Europe PubMed Central

PubMed publication ID

24778419

retrieved

28 July 2017

ResearchGate publication ID

261956688

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