Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. (Q34282364)

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7 February 2020

title

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia (English)

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7 February 2020

author name string

Pinelopi P Kapitsinou

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7 February 2020

Qingdu Liu

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Travis L Unger

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7 February 2020

Olena Davidoff

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7 February 2020

Brian Keith

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7 February 2020

Jonathan A Epstein

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Sheri L Moores

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7 February 2020

Connie L Erickson-Miller

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language of work or name

English

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publication date

13 July 2010

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7 February 2020

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volume

116

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issue

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page(s)

3039-3048

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The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.

7 February 2020

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HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.

6 July 2018

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Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency

6 July 2018

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Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis

6 July 2018

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6 July 2018

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6 July 2018

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HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques

6 July 2018

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Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

6 July 2018

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Acute postnatal ablation of Hif-2alpha results in anemia

6 July 2018

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Pathogenesis of renal anemia

6 July 2018

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Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development

6 July 2018

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Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice

6 July 2018

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HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner

6 July 2018

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Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

6 July 2018

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Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression

6 July 2018

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Oxygen sensing by HIF hydroxylases

6 July 2018

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A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylation

6 July 2018

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Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

6 July 2018

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6 July 2018

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Inactivation of erythropoietin leads to defects in cardiac morphogenesis

6 July 2018

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Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

6 July 2018

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Erythropoietin mRNA expression in human fetal and neonatal tissue.

6 July 2018

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

6 July 2018

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Developmental regulation of erythropoietin and erythropoiesis

6 July 2018

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Purification and characterization of hypoxia-inducible factor 1

6 July 2018

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Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells.

6 July 2018

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

6 July 2018

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6 July 2018

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6 July 2018

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Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration

6 July 2018

1 reference

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Secondary erythrocytosis due to a cerebellar hemangioblastoma: demonstration of erythropoietin mRNA in the tumor

6 July 2018

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Age-dependent expression of the erythropoietin gene in rat liver and kidneys

6 July 2018

1 reference

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

6 July 2018

1 reference

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Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974609

The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974609

Hepatic erythropoietin gene regulation by GATA-4.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974609

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974609

hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo

28 October 2018

1 reference

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Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic mice

28 October 2018

1 reference

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Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974609

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

28 October 2018

1 reference

12 December 2020

The liver as a source of extrarenal erythropoietin production

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12 December 2020

Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization

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12 December 2020

Localization of cells producing erythropoietin in murine liver by in situ hybridization

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12 December 2020

Organ distribution of erythropoietin messenger RNA in normal and uremic rats

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12 December 2020

Co-localization of erythropoietin mRNA and ecto-5'-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin

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12 December 2020

Identification of the renal erythropoietin-producing cells using transgenic mice

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12 December 2020

10.1182/BLOOD-2010-02-270322

Identifiers

DOI

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7 February 2020

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7 February 2020

PubMed publication ID

20628150

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