Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium (Q33556272)

28 July 2017

title

Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium (English)

1 reference

28 July 2017

Kyle Den Beste

0 references

Patrick O Humbert

0 references

Asma Nusrat

1 reference

28 July 2017

Andrei I Ivanov

1 reference

28 July 2017

Cheryl Young

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28 July 2017

Christopher T Capaldo

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28 July 2017

Patrick Brennwald

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28 July 2017

Charles A Parkos

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28 July 2017

language of work or name

English

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publication date

3 December 2009

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The American Journal of Pathology

28 July 2017

published in

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28 July 2017

volume

176

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28 July 2017

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28 July 2017

page(s)

134-145

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Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions

28 July 2017

cites work

1 reference

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Scribble interacts with beta-catenin to localize synaptic vesicles to synapses

21 June 2018

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Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility

21 June 2018

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Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

21 June 2018

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Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

21 June 2018

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Lipid rafts mediate internalization of beta1-integrin in migrating intestinal epithelial cells

21 June 2018

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Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

21 June 2018

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hScrib, a human homologue of Drosophila neoplastic tumor suppressor, is a novel death substrate targeted by caspase during the process of apoptosis

21 June 2018

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21 June 2018

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Regulation of cell polarity during epithelial morphogenesis

21 June 2018

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21 June 2018

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21 June 2018

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The density of small tight junction pores varies among cell types and is increased by expression of claudin-2.

21 June 2018

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Tight junction and polarity interaction in the transporting epithelial phenotype.

21 June 2018

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Polarity complex proteins

21 June 2018

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The PAR proteins: fundamental players in animal cell polarization

21 June 2018

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Intestinal permeability and its relevance for absorption and elimination

21 June 2018

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Crosstalk of tight junction components with signaling pathways

21 June 2018

1 reference

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Structural organization of the tight junctions

21 June 2018

1 reference

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Adherens and tight junctions: structure, function and connections to the actin cytoskeleton

21 June 2018

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A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctions

21 June 2018

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21 June 2018

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21 June 2018

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Human scribble accumulates in colorectal neoplasia in association with an altered distribution of beta-catenin

21 June 2018

1 reference

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Autonomic nervous system and secretion across the intestinal mucosal surface

21 June 2018

1 reference

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The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation

21 June 2018

1 reference

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Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application

21 June 2018

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Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells

21 June 2018

1 reference

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The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge

21 June 2018

1 reference

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Scribble associates with two polarity proteins, Lgl2 and Vangl2, via distinct molecular domains

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Tight junctions and cell polarity.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity.

21 June 2018

1 reference

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Microtubules regulate disassembly of epithelial apical junctions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Mitogen-activated protein kinases, adherens junction dynamics, and spermatogenesis: a review of recent data

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Junctional recruitment of mammalian Scribble relies on E-cadherin engagement

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Chronic inflammation, apoptosis and (pre-)malignant lesions in the gastro-intestinal tract

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Intestinal absorption in health and disease: micronutrients

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Basolateral targeting by leucine-rich repeat domains in epithelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Endocytosis of Epithelial Apical Junctional Proteins by a Clathrin-mediated Pathway into a Unique Storage Compartment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Composition and formation of intercellular junctions in epithelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Epithelial cell polarity and cell junctions in Drosophila

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Multifunctional strands in tight junctions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Localization of apical epithelial determinants by the basolateral PDZ protein Scribble

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Regulation of the movement of solutes across tight junctions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Vectorial targeting of apical and basolateral plasma membrane proteins in a human adenocarcinoma epithelial cell line

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Role of calcium in tight junction formation between epithelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

c-Jun N-terminal kinase mediates disassembly of apical junctions in model intestinal epithelia.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Myosin II regulates the shape of three-dimensional intestinal epithelial cysts

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Localization of PDZ domain containing proteins Discs Large-1 and Scribble in the mouse eye.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Integrated activity of PDZ protein complexes regulates epithelial polarity

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797876

10.2353/AJPATH.2010.090220

31 October 2018

Identifiers

DOI

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28 July 2017

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28 July 2017

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