Intestinal permeability and its relevance for absorption and elimination (Q36985043)

17 August 2017

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title

Intestinal permeability and its relevance for absorption and elimination (English)

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17 August 2017

Lennernäs H

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17 August 2017

language of work or name

English

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publication date

1 October 2007

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17 August 2017

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17 August 2017

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17 August 2017

issue

10-11

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17 August 2017

page(s)

1015-1051

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Carrier-mediated jejunal absorption of conjugated bile acids in the guinea pig.

17 August 2017

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Quinidine reduces biliary clearance of digoxin in man.

21 January 2018

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Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut.

21 January 2018

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Regional transport and metabolism of ropivacaine and its CYP3A4 metabolite PPX in human intestine

21 January 2018

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Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development

21 January 2018

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Pharmacokinetic evaluation in man of terbutaline given as separate enantiomers and as the racemate

21 January 2018

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Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in Caco-2 cells.

21 January 2018

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Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).

21 January 2018

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Saturable absorptive transport of the hydrophilic organic cation ranitidine in Caco-2 cells: role of pH-dependent organic cation uptake system and P-glycoprotein.

21 January 2018

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Controlled release technologies for drug delivery

21 January 2018

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Keynote review: intestinal Peyer's patch M cells and oral vaccine targeting.

21 January 2018

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Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

21 January 2018

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Human jejunal permeability of cyclosporin A: influence of surfactants on P-glycoprotein efflux in Caco-2 cells

21 January 2018

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Mechanisms of clinically relevant drug interactions associated with tacrolimus

21 January 2018

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Comparison of P-glycoprotein-mediated drug-digoxin interactions in Caco-2 with human and rodent intestine: relevance to in vivo prediction.

21 January 2018

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Influence of morphometric factors on quantitation of paracellular permeability of intestinal epithelia in vitro.

21 January 2018

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In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model

21 January 2018

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Molecular and integrative physiology of intestinal peptide transport

21 January 2018

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The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology

21 January 2018

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P-glycoprotein-mediated intestinal and biliary digoxin transport in humans

21 January 2018

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Absorption potential: estimating the fraction absorbed for orally administered compounds

21 January 2018

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Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1).

21 January 2018

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CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell lines suitable for drug transport studies

21 January 2018

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Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effect

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

Comparison between permeability coefficients in rat and human jejunum

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

Jejunal permeability in humans in vivo and rats in situ: investigation of molecular size selectivity and solvent drag

21 January 2018

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Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

In vitro-in vivo correlation of hepatobiliary drug clearance in humans.

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

Intestinal drug transporter expression and the impact of grapefruit juice in humans

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

The role of ABC transporters in drug resistance, metabolism and toxicity

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

Intestinal microflora: metabolism of drugs and carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Bioavailability and pharmacokinetics of cimetidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Paracetamol absorption from different sites in the human small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

21 January 2018

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5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

No effect of probenecid on the renal and biliary clearances of digoxin in man.

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

Stereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The stereoisomers quinine and quinidine exhibit a marked stereoselectivity in the inhibition of hepatobiliary transport of cardiac glycosides

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

Multiple molecular mechanisms for multidrug resistance transporters

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin

21 January 2018

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Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

Drug interaction studies: study design, data analysis, and implications for dosing and labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Determination of intrinsic membrane transport parameters from perfused intestine experiments: A boundary layer approach to estimating the aqueous and unbiased membrane permeabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Kinetic considerations for the quantitative assessment of efflux activity and inhibition: implications for understanding and predicting the effects of efflux inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Transporter-mediated intestinal absorption of fexofenadine in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

A perfusion bioreactor for intestinal tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Investigations of the in-vitro metabolism of three opioid tetrapeptides by pancreatic and intestinal enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Improvement of oral drug treatment by temporary inhibition of drug transporters and/or cytochrome P450 in the gastrointestinal tract and liver: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Intestinal drug transporters: in vivo function and clinical importance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The relationship between membrane fluidity and permeabilities to water, solutes, ammonia, and protons

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Human Jejunal Effective Permeability and Its Correlation with Preclinical Drug Absorption Models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Human intestinal permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Intestinal drug absorption and bioavailability: beyond involvement of single transport function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Intestinal drug absorption during induced net water absorption in man; a mechanistic study using antipyrine, atenolol and enalaprilat

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

Regional rectal perfusion: a new in vivo approach to study rectal drug absorption in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The influence of caprate on rectal absorption of phenoxymethylpenicillin: experience from an in-vivo perfusion in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The effect of amiloride on the in vivo effective permeability of amoxicillin in human jejunum: experience from a regional perfusion technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The effect of L-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Drug-drug interaction mediated by inhibition and induction of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Clinical relevance of P-glycoprotein in drug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Role of P-glycoprotein in pharmacokinetics: clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Regional intestinal absorption and biliary excretion of fluvastatin in the rat: possible involvement of mrp2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Variable expression of CYP and Pgp genes in the human small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

EUFEPS conference on drug transporters at Copenhagen: integrative approaches in ADME research

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

The method of intraluminal perfusion of the human small intestine. II. Absorption studies in health

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The method of intraluminal perfusion of the human small intestine. I. Principle and technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Nonlinearity of amoxicillin absorption kinetics in human.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Hepatic clearance of drugs. III. Additional experimental evidence supporting the "well-stirred" model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liver in situ pr

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded lipid nanocapsules

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Transport characteristics of fexofenadine in the Caco-2 cell model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The method of intraluminal perfusion of the human small intestine. 3. Absorption studies in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Pharmacokinetics of felodipine in patients with liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Effects of a non-absorbable osmotic load on drug absorption in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The influence of gastrointestinal transit on drug absorption in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Pharmacokinetics, pharmacodynamics, and tolerance of single- and multiple-dose fexofenadine hydrochloride in healthy male volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Molecular and pharmacokinetic properties of 222 commercially available oral drugs in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The effect of ketoconazole on the jejunal permeability and CYP3A metabolism of (R/S)-verapamil in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Modulation of oral bioavailability of anticancer drugs: from mouse to man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Presentation of a structurally diverse and commercially available drug data set for correlation and benchmarking studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Pharmacokinetics and metabolism in early drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The pivotal role of hepatocytes in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Delivery aspects of small peptides and substrates for peptide transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Region-dependent modulation of intestinal permeability by drug efflux transporters: in vitro studies in mdr1a(-/-) mouse intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Human jejunal permeability of two polar drugs: cimetidine and ranitidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Tacrolimus is a class II low-solubility high-permeability drug: the effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The site-specific transport and metabolism of tacrolimus in rat small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Membrane transport of drugs in different regions of the intestinal tract of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Innovative methods to study human intestinal drug metabolism in vitro: precision-cut slices compared with ussing chamber preparations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Hydrogen bonding descriptors in the prediction of human in vivo intestinal permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250701704819

The permeability coefficient of the wall of a villous membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Dependence of intestinal absorption in vivo on the unstirred layer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Folate absorption from folate-fortified and processed foods using a human ileostomy model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Colonic health: fermentation and short chain fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701704819

10.1080/00498250701704819

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference