Discovery of novel proteasome inhibitors using a high-content cell-based screening system (Q33521189)

27 July 2017

title

Discovery of novel proteasome inhibitors using a high-content cell-based screening system (English)

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27 July 2017

Varda Rotter

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27 July 2017

Irena Lavelin

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27 July 2017

Avital Beer

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27 July 2017

Zvi Kam

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27 July 2017

Moshe Oren

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27 July 2017

Ami Navon

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27 July 2017

Benjamin Geiger

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27 July 2017

language of work or name

English

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publication date

30 December 2009

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27 July 2017

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27 July 2017

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27 July 2017

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27 July 2017

page(s)

e8503

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Creative Commons Attribution 4.0 International

27 July 2017

start time

30 December 2009

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction

21 June 2018

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Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

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Proteasome inhibitors: from research tools to drug candidates

21 June 2018

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Impairment of the ubiquitin-proteasome system by protein aggregation

21 June 2018

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Use of short-lived green fluorescent protein for the detection of proteasome inhibition

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21 June 2018

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21 June 2018

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Regulation of β-Catenin Levels and Localization by Overexpression of Plakoglobin and Inhibition of the Ubiquitin-Proteasome System

21 June 2018

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Structure of 20S proteasome from yeast at 2.4 A resolution

21 June 2018

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21 June 2018

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Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

21 June 2018

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A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

21 June 2018

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 June 2018

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Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

21 June 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0008503

Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome

21 January 2018

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Cell-based bioluminescent assays for all three proteasome activities in a homogeneous format.

21 January 2018

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Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress.

21 January 2018

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Targeting the proteasome pathway

31 October 2018

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12 December 2020

Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

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12 December 2020

Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells

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12 December 2020

Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

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12 December 2020

MDM2-dependent ubiquitination of nuclear and cytoplasmic P53

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12 December 2020

Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells

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12 December 2020

Total synthesis and biological activity of lactacystin, omuralide and analogs

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12 December 2020

10.1371/JOURNAL.PONE.0008503

Identifiers

DOI

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27 July 2017

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27 July 2017

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