NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells (Q35850681)

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scientific article published on 13 March 2007

Language	Label	Description	Also known as
English	NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells	scientific article published on 13 March 2007

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

5

object named as

Mark Munsell

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Europe PubMed Central

PMC publication ID

10 August 2017

author name string

Claudia P Miller

1

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Kechen Ban

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Melanie E Dujka

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

David J McConkey

4

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Michael Palladino

6

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Joya Chandra

7

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

language of work or name

0 references

publication date

13 March 2007

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Europe PubMed Central

PMC publication ID

10 August 2017

number of pages

11

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based on heuristic

inferred from page(s)

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Europe PubMed Central

PMC publication ID

10 August 2017

110

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Europe PubMed Central

PMC publication ID

10 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

267-277

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Proteasome inhibition with bortezomib: a new therapeutic strategy for non-Hodgkin's lymphoma

1 reference

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11 July 2018

Mitochondrial membrane permeabilization: the sine qua non for cell death

1 reference

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11 July 2018

Proteasome inhibitors in lung cancer

1 reference

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The proteasome and proteasome inhibitors in cancer therapy

1 reference

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11 July 2018

Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

1 reference

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Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance

1 reference

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

1 reference

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Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

1 reference

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Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein

1 reference

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11 July 2018

Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor

1 reference

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11 July 2018

Proteasome inhibition as a novel therapeutic target in human cancer.

1 reference

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11 July 2018

Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

1 reference

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11 July 2018

The proteasome: a proteolytic nanomachine of cell regulation and waste disposal

1 reference

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11 July 2018

Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitor-induced apoptosis through the generation of reactive oxygen species

1 reference

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11 July 2018

Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells.

1 reference

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11 July 2018

Development of the proteasome inhibitor Velcade (Bortezomib).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

The development of proteasome inhibitors as anticancer drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

The proteasome: a suitable antineoplastic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

Molecular sequelae of proteasome inhibition in human multiple myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

Proteasome inhibitors stimulate activator protein-1 pathway via reactive oxygen species production.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

Catalytic activities of the 20 S proteasome, a multicatalytic proteinase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

The biochemistry of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

Structure and functions of the 20S and 26S proteasomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

11 July 2018

The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

24 September 2018

Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis.

1 reference

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24 September 2018

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

24 September 2018

The proteasome as a novel target for the treatment of breast cancer

1 reference

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24 September 2018

The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib

1 reference

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24 September 2018

Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts

1 reference

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24 September 2018

Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells

1 reference

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24 September 2018

The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells

1 reference

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24 September 2018

The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571.

1 reference

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24 September 2018

Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

24 September 2018

The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1896116

24 September 2018

Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17356134

12 December 2020

based on heuristic

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Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib

1 reference

https://pubmed.ncbi.nlm.nih.gov/17356134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/17356134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The apoptotic effects and synergistic interaction of sodium butyrate and MG132 in human retinoblastoma Y79 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17356134

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown

1 reference

https://pubmed.ncbi.nlm.nih.gov/17356134

12 December 2020

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Total synthesis and biological activity of lactacystin, omuralide and analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17356134

12 December 2020

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Proteasome inhibition measurements: clinical application

1 reference

https://pubmed.ncbi.nlm.nih.gov/17356134

12 December 2020

based on heuristic

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Identifiers

10.1182/BLOOD-2006-03-013128

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

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