Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system (Q33451969)

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English	Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

author name string

Michael H Court

1

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

language of work or name

0 references

publication date

1 February 2010

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Drug Metabolism Reviews

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Europe PubMed Central

PubMed publication ID

26 July 2017

42

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

209-224

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10

1 reference

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21 January 2018

Evidence for phosphorylation requirement for human bilirubin UDP-glucuronosyltransferase (UGT1A1) activity

1 reference

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21 January 2018

Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism

1 reference

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21 January 2018

Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines

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21 January 2018

UGT1A6 polymorphism and salicylic acid glucuronidation following aspirin

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21 January 2018

Morphine metabolism in children

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21 January 2018

Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications

1 reference

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21 January 2018

Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases

1 reference

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21 January 2018

Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

1 reference

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21 January 2018

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

1 reference

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21 January 2018

Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction

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21 January 2018

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

1 reference

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21 January 2018

Glucuronidation in humans. Pharmacogenetic and developmental aspects

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21 January 2018

A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity

1 reference

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21 January 2018

Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.

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21 January 2018

Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

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21 January 2018

UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver

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21 January 2018

Increased metabolism of acetaminophen in chronically alcoholic patients

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21 January 2018

Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part I).

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21 January 2018

Gender has a small but statistically significant effect on clearance of CYP3A substrate drugs

1 reference

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21 January 2018

Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo

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21 January 2018

Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes

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21 January 2018

The ontogeny of drug metabolism enzymes and implications for adverse drug events

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21 January 2018

Predicting response to lithium in mood disorders: role of genetic polymorphisms

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21 January 2018

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

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21 January 2018

Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene

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21 January 2018

Ethanol-dependent induction of bilirubin UDP-glucuronosyl-transferase in rat liver is mediated by Kupffer cells

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21 January 2018

Pharmacokinetics and drug metabolism in the elderly

1 reference

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21 January 2018

Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6.

1 reference

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21 January 2018

Serotonin (5-hydroxytryptamine) glucuronidation in vitro: assay development, human liver microsome activities and species differences

1 reference

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21 January 2018

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation

1 reference

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21 January 2018

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S).

1 reference

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21 January 2018

Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6.

1 reference

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21 January 2018

Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation

1 reference

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21 January 2018

Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes

1 reference

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21 January 2018

Development of multiple activities of UDP-glucuronyltransferase in human liver

1 reference

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21 January 2018

Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers

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21 January 2018

Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase

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21 January 2018

UGT1A6 genotype-related pharmacokinetics of deferiprone (L1) in healthy volunteers.

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21 January 2018

The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms

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Influence of sex and oral contraceptive steroids on paracetamol metabolism

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In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises

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21 January 2018

Drug glucuronidation in humans

1 reference

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21 January 2018

Pediatric development of glucuronidation: the ontogeny of hepatic UGT1A4.

1 reference

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21 January 2018

Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver

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21 January 2018

Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells

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21 January 2018

Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines.

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21 January 2018

Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes

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21 January 2018

The relationship between the response of clinical symptoms and plasma olanzapine concentration, based on pharmacogenetics: Juntendo University Schizophrenia Projects (JUSP).

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21 January 2018

Kinetics of diazepam, midazolam, and lorazepam in cigarette smokers

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21 January 2018

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

1 reference

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21 January 2018

Distribution of UDP-glucuronyltransferase in different human foetal tissues

1 reference

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21 January 2018

The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

1 reference

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21 January 2018

Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes

1 reference

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21 January 2018

Lack of association between common polymorphisms in UGT1A9 and gene expression and activity

1 reference

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21 January 2018

Acetaminophen: Potentially Toxic Metabolite Formed by Human Fetal and Adult Liver Microsomes and Isolated Fetal Liver Cells

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209288

21 January 2018

Differential effect of cigarette smoking on antipyrine oxidation versus acetaminophen conjugation

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209288

21 January 2018

Developmental aspects of human hepatic drug glucuronidation in young children and adults

1 reference

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21 January 2018

Effect of genetic polymorphisms in UDP-glucuronosyltransferase 1A6 (UGT1A6) on acetylsalicylic acid metabolism in healthy female volunteers.

1 reference

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21 January 2018

Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes

1 reference

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21 January 2018

A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity

1 reference

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21 January 2018

Interindividual and interethnic differences in the demethylation and glucuronidation of codeine

1 reference

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21 January 2018

Epirubicin glucuronidation and UGT2B7 developmental expression.

1 reference

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21 January 2018

Comparative study of clofibric acid and bilirubin glucuronidation in human liver microsomes

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21 January 2018

Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6174030

25 November 2018

Sex differences in the expression of hepatic drug metabolizing enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6174030

25 November 2018

Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6174030

25 November 2018

Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6174030

25 November 2018

Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6174030

25 November 2018

Oxazepam kinetics: effects of age and sex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6174030

25 November 2018

Drugs and fetal metabolism

1 reference

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25 November 2018

The inadequacy of perinatal glucuronidation: immunoblot analysis of the developmental expression of individual UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6174030

25 November 2018

Development of human liver UDP-glucuronosyltransferases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6174030

25 November 2018

Transcriptional induction of bilirubin UDP-glucuronosyltransrase by ethanol in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paracetamol as a test drug to determine glucuronide formation in man. Effects of inducers and of smoking

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of combined UDP-glucuronosyltransferase (UGT) 1A1*28 and 1A6*2 on paracetamol pharmacokinetics in beta-thalassemia/HbE

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alcohol up-regulates UDP-glucuronosyltransferase mRNA expression in rat liver and in primary rat hepatocyte culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphine glucuronidation in human fetal and adult liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of SN-38 exposure, UGT1A1*28 polymorphism, and baseline bilirubin level in predicting severe irinotecan toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE NOVEL UGT1A9 INTRONIC I399 POLYMORPHISM APPEARS AS A PREDICTOR OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN GLUCURONIDATION LEVELS IN THE LIVER

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of oxazepam in relation to age, sex, and cigarette smoking

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carbamazepine and cigarette smoking induce differentially the metabolism of codeine in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Pharmacokinetics and metabolism of acetaminophen in normal, alcoholic and cirrhotic subjects]

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Impact of UGT1A8, UGT1A9, and UGT2B7 Genetic Polymorphisms on the Pharmacokinetic Profile of Mycophenolic Acid After a Single Oral Dose in Healthy Volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of cytochrome P-448 iso-enzymes and related glucuronyltransferases in the human liver by cigarette smoking

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sex-difference and the effects of smoking and oral contraceptive steroids on the kinetics of diflunisal

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotyping of cytochrome P450 2E1 in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UDP glucuronosyltransferase mRNA levels in human liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver volume as a determinant of drug clearance in children and adolescents

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic ethanol consumption causes increased glucuronidation of morphine in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3109/03602530903209288

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

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