Pharmacokinetics and drug metabolism in the elderly (Q37514319)

20 August 2017

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title

Pharmacokinetics and drug metabolism in the elderly (English)

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20 August 2017

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Ulrich Klotz

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20 August 2017

language of work or name

English

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publication date

1 January 2009

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20 August 2017

published in

Drug Metabolism Reviews

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20 August 2017

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20 August 2017

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20 August 2017

page(s)

67-76

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Pharmacokinetics of isoniazid in the elderly

20 August 2017

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The effect of age on the pharmacokinetics and pharmacodynamics of midazolam

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Aging Liver. A review

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Changes in plasma protein binding have little clinical relevance

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Sex, race, and smoking impact olanzapine exposure.

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P-glycoprotein function in the elderly

21 January 2018

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Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib

21 January 2018

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Free drug metabolic clearance in elderly people.

21 January 2018

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Adverse drug events in the elderly

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Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

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Regulatory aspects of pharmacokinetic profiling in special populations: a European perspective

21 January 2018

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Time response of cytochrome P450 1A2 activity on cessation of heavy smoking

21 January 2018

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Paroxetine: population pharmacokinetic analysis in late-life depression using sparse concentration sampling

21 January 2018

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Effects of uptake and efflux transporter inhibition on erythromycin breath test results

21 January 2018

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Gut wall metabolism of verapamil in older people: effects of rifampicin-mediated enzyme induction

21 January 2018

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The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity

21 January 2018

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Implications of altered drug disposition in the elderly: studies of benzodiazepines

21 January 2018

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A cystatin C-based formula without anthropometric variables estimates glomerular filtration rate better than creatinine clearance using the Cockcroft-Gault formula.

21 January 2018

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Differential pharmacokinetics of digoxin in elderly patients

21 January 2018

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Age and nature of operation influence the pharmacokinetics of midazolam

21 January 2018

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Drug metabolism and drug interactions in the elderly

21 January 2018

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Clinical pharmacology in the geriatric patient

21 January 2018

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Plasma esterases and inflammation in ageing and frailty

21 January 2018

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Effect of age and gender on the activity of human hepatic CYP3A

21 January 2018

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The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics

21 January 2018

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Parenchymal liver disease in the elderly

21 January 2018

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Drug metabolism and ageing

21 January 2018

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The role of pharmacogenetics in the metabolism of antiepileptic drugs: pharmacokinetic and therapeutic implications

21 January 2018

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The effects of age and liver disease on the disposition and elimination of diazepam in adult man

21 January 2018

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Alterations in the disposition of differently cleared drugs in patients with cirrhosis

21 January 2018

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CYP2C19 polymorphism and proton pump inhibitors

21 January 2018

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The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity

21 January 2018

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Estimation of glomerular filtration rate in the elderly: Cockcroft-Gault formula versus modification of diet in renal disease formula

21 January 2018

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The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance.

21 January 2018

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Role of P-glycoprotein in pharmacokinetics: clinical implications

21 January 2018

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Longitudinal studies on the rate of decline in renal function with age.

21 January 2018

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Pharmacokinetics of intravenous and oral midazolam in plasma and saliva in humans: usefulness of saliva as matrix for CYP3A phenotyping

21 January 2018

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21 January 2018

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The challenge of managing drug interactions in elderly people

21 January 2018

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Aging biology and geriatric clinical pharmacology

21 January 2018

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Cystatin C reference values and aging

21 January 2018

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The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

21 January 2018

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Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients undergoing tooth extraction

21 January 2018

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Liver function and phase I drug metabolism in the elderly: a paradox

21 January 2018

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Erythromycin breath test results in elderly, very elderly, and frail elderly persons

21 January 2018

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The current state of knowledge on age, sex, and their interactions on clinical pharmacology

21 January 2018

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Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance.

21 January 2018

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Clinical use and pharmacological properties of selective COX-2 inhibitors

21 January 2018

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The clinical implications of ageing for rational drug therapy

21 January 2018

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A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants

21 January 2018

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Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers

21 January 2018

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Differential pharmacokinetics of lithium in elderly patients

21 January 2018

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The impact of efflux transporters in the brain on the development of drugs for CNS disorders

21 January 2018

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Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography

21 January 2018

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Pharmacokinetics and therapeutic drug monitoring of gentamicin in the elderly

21 January 2018

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Drug dosage in the elderly. Is it rational?

21 January 2018

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Pharmacokinetic dosage guidelines for elderly subjects

21 January 2018

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Estimation of glomerular filtration rate in the elderly: a comparison of creatinine-based formulae with serum cystatin C.

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530902722679

The effect of ageing on cytochrome p450 enzymes: consequences for drug biotransformation in the elderly

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530902722679

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530902722679

The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530902722679

The aging liver: structural and functional changes and their consequences for drug treatment in old age.

21 January 2018

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The Relations of Body Composition and Adiposity Measures to Ill Health and Physical Disability in Elderly Men

21 January 2018

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10.1080/03602530902722679

21 January 2018

Identifiers

DOI

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20 August 2017

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