The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies (Q33337217)

25 July 2017

title

The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies (English)

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25 July 2017

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Philippe Froguel

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Hélène Choquet

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Michel Marre

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David Meyre

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25 July 2017

Kevin T Nead

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25 July 2017

Stéphane Cauchi

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25 July 2017

Fritz Horber

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25 July 2017

Natascha Potoczna

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25 July 2017

Beverley Balkau

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25 July 2017

Guillaume Charpentier

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25 July 2017

publication date

22 May 2008

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25 July 2017

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25 July 2017

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25 July 2017

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Effects of TCF7L2 polymorphisms on obesity in European populations

25 July 2017

cites work

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The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects

21 June 2018

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Role of ENPP1 on adipocyte maturation

21 June 2018

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

21 June 2018

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A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

21 June 2018

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Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans

21 June 2018

1 reference

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A genome-wide association study identifies novel risk loci for type 2 diabetes

21 June 2018

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Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone

21 June 2018

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Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

21 June 2018

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Mechanisms linking obesity to insulin resistance and type 2 diabetes

21 June 2018

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Common variants in HNF-1 alpha and risk of type 2 diabetes

21 June 2018

1 reference

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Islet beta cell failure in type 2 diabetes

21 June 2018

1 reference

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K-value and low insulin secretion in a non-obese white population: predicted glucose tolerance after 25 years

21 June 2018

1 reference

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Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

21 June 2018

1 reference

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Type 2 diabetes: principles of pathogenesis and therapy

21 June 2018

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Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population

21 June 2018

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Whole-genome patterns of common DNA variation in three human populations

21 June 2018

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The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3

21 June 2018

1 reference

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Binge eating as a major phenotype of melanocortin 4 receptor gene mutations

21 June 2018

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Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001

21 June 2018

1 reference

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 June 2018

1 reference

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 June 2018

1 reference

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Insulin signalling and the regulation of glucose and lipid metabolism

21 June 2018

1 reference

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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

21 June 2018

1 reference

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The hormone resistin links obesity to diabetes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2412856

21 June 2018

1 reference

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Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2412856

Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2412856

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2412856

Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2412856

Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2412856

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects

21 June 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-9-45

Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-9-45

Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-9-45

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-9-45

Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-9-45

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-9-45

Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-9-45

The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-9-45

Islet dysfunction in insulin resistance involves impaired insulin secretion and increased glucagon secretion in postmenopausal women with impaired glucose tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-9-45

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-9-45

Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2412856

Studies in 3,523 Norwegians and Meta-Analysis in 11,571 Subjects Indicate That Variants in the Hepatocyte Nuclear Factor 4 (HNF4A) P2 Region Are Associated With Type 2 Diabetes in Scandinavians

31 October 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-9-45

Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2350-9-45

The K121Q Polymorphism of the ENPP1/PC-1 Gene Is Associated With Insulin Resistance/Atherogenic Phenotypes, Including Earlier Onset of Type 2 Diabetes and Myocardial Infarction

21 January 2018

1 reference

12 December 2020

New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals

1 reference

12 December 2020

No Evidence of Association of ENPP1 Variants With Type 2 Diabetes or Obesity in a Study of 8,089 U.K. Caucasians

1 reference

12 December 2020

Heterogeneous effect of peroxisome proliferator-activated receptor gamma2 Ala12 variant on type 2 diabetes risk

1 reference

12 December 2020

Common Variants of the Hepatocyte Nuclear Factor-4 P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population

1 reference

12 December 2020

[An epidemiologic survey from a network of French Health Examination Centres, (D.E.S.I.R.): epidemiologic data on the insulin resistance syndrome]

1 reference

12 December 2020

Mutation in the HNF-4alpha gene affects insulin secretion and triglyceride metabolism

1 reference

12 December 2020

Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2350-9-45

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Dimensions Publication ID

25 July 2017

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25 July 2017

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