Type 2 diabetes: principles of pathogenesis and therapy (Q36095054)

12 August 2017

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title

Type 2 diabetes: principles of pathogenesis and therapy (English)

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12 August 2017

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Michael Stumvoll

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12 August 2017

Barry J Goldstein

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12 August 2017

Timon W van Haeften

series ordinal

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12 August 2017

language of work or name

English

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publication date

1 April 2005

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12 August 2017

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12 August 2017

volume

365

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12 August 2017

issue

9467

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12 August 2017

page(s)

1333-1346

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Global and societal implications of the diabetes epidemic

12 August 2017

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Risk of diabetes in offspring of parents with non-insulin-dependent diabetes

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Prevalence of Diabetes and Glucose Intolerance in 199 Offspring of Thirty-seven Conjugal Diabetic Parents

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7 January 2021

Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland

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Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins

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Diabetes in the Old Order Amish: characterization and heritability analysis of the Amish Family Diabetes Study

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Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins.

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7 January 2021

Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators

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7 January 2021

Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin

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7 January 2021

Family and genetic studies of indices of insulin sensitivity and insulin secretion in Pima Indians

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7 January 2021

Familial resemblance for glucose and insulin metabolism indices derived from an intravenous glucose tolerance test in Blacks and Whites of the HERITAGE Family Study

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7 January 2021

Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects--experiences from relatives and twin studies

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7 January 2021

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

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7 January 2021

The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease

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7 January 2021

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7 January 2021

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

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7 January 2021

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7 January 2021

Carbohydrate metabolism in non-insulin-dependent diabetes mellitus

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7 January 2021

Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance

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7 January 2021

Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus

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7 January 2021

Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.

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7 January 2021

Failure of adipocyte differentiation causes type II diabetes mellitus?

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7 January 2021

Intramyocellular lipids and insulin resistance

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7 January 2021

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

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7 January 2021

Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes

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7 January 2021

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

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7 January 2021

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

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7 January 2021

Extended longevity in mice lacking the insulin receptor in adipose tissue

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7 January 2021

Role of brain insulin receptor in control of body weight and reproduction

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7 January 2021

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

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7 January 2021

IRS proteins and the common path to diabetes

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7 January 2021

Insulin resistance: a phosphorylation-based uncoupling of insulin signaling

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7 January 2021

Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

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7 January 2021

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

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7 January 2021

Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis

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7 January 2021

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

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7 January 2021

Cellular mechanisms of insulin resistance

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7 January 2021

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

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7 January 2021

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

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7 January 2021

Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes

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7 January 2021

Molecular mechanisms of insulin resistance and the role of the adipocyte

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7 January 2021

Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes

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7 January 2021

Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.

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7 January 2021

Adiponectin: A novel adipokine linking adipocytes and vascular function

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7 January 2021

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

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7 January 2021

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation

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7 January 2021

Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes

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7 January 2021

Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes

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7 January 2021

Role of AMP-activated protein kinase in mechanism of metformin action

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7 January 2021

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

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7 January 2021

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

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7 January 2021

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

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7 January 2021

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

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7 January 2021

Prevention of fat-induced insulin resistance by salicylate

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7 January 2021

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

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7 January 2021

Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance

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7 January 2021

Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin

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7 January 2021

Obesity-induced inflammatory changes in adipose tissue.

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7 January 2021

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

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7 January 2021

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

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7 January 2021

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

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7 January 2021

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

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7 January 2021

Disturbances in beta-cell function in impaired fasting glycemia.

1 reference

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7 January 2021

Altered homeostatic adaptation of first- and second-phase beta-cell secretion in the offspring of patients with type 2 diabetes: studies with a minimal model to assess beta-cell function

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7 January 2021

Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection

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7 January 2021

Coefficient of failure: a methodology for examining longitudinal beta-cell function in Type 2 diabetes

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7 January 2021

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

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7 January 2021

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

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7 January 2021

Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes

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7 January 2021

Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes

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7 January 2021

Candidate genes for type 2 diabetes

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7 January 2021

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

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7 January 2021

Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists

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7 January 2021

Thiazolidinediones: an update.

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7 January 2021

PPARgamma, the ultimate thrifty gene

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7 January 2021

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

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7 January 2021

Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes

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7 January 2021

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

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7 January 2021

Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant caucasians

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7 January 2021

A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians

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7 January 2021

The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism

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7 January 2021

The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells

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7 January 2021

The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans

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7 January 2021

Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus

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7 January 2021

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

1 reference

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7 January 2021

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region

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7 January 2021

Molecular insights into insulin action and secretion

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7 January 2021

Growing evidence for diabetes susceptibility genes from genome scan data

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7 January 2021

Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene

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7 January 2021

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

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7 January 2021

Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization

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7 January 2021

Structure, activation, and biology of calpain

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7 January 2021

Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians

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7 January 2021

Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese

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7 January 2021

Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom

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7 January 2021

Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population

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7 January 2021

Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies

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7 January 2021

Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility

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7 January 2021

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

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7 January 2021

Calpains play a role in insulin secretion and action

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7 January 2021

Parallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes

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7 January 2021

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes

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7 January 2021

The insulin gene VNTR, type 2 diabetes and birth weight

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7 January 2021

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0140-6736%2805%2961032-X

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7 January 2021

Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin

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7 January 2021

Progress with thiazolidinediones in the management of type 2 diabetes mellitus

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7 January 2021

Glitazones and the management of insulin resistance: what they do and how might they be used

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7 January 2021

Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003.

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Antiatherogenic properties of metformin: the experimental evidence.

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7 January 2021

The STOP-NIDDM Trial: an international study on the efficacy of an alpha-glucosidase inhibitor to prevent type 2 diabetes in a population with impaired glucose tolerance: rationale, design, and preliminary screening data. Study to Prevent Non-Insuli

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7 January 2021

The role of sulphonylureas in the management of type 2 diabetes mellitus

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7 January 2021

GUIDE study: double-blind comparison of once-daily gliclazide MR and glimepiride in type 2 diabetic patients

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7 January 2021

Insulin as an anti-inflammatory and antiatherosclerotic hormone

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7 January 2021

Therapeutic strategies based on glucagon-like peptide 1.

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7 January 2021

Diabetes and atherosclerosis: epidemiology, pathophysiology, and management

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Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators

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Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study

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MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial

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Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)

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7 January 2021

Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial

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Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study

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Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women

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7 January 2021

Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial

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7 January 2021

A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance

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Identifiers

DOI

1 reference

release_ibcv5ojxxfbdrhqcx5zyfp5q6q

12 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ibcv5ojxxfbdrhqcx5zyfp5q6q

24 November 2022

mapped directly with Wikidata item

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