RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core (Q30556912)

19 August 2017

RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core (English)

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19 August 2017

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1 reference

Zhichao Miao

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Reinhard Georg Lührmann

series ordinal

object named as

Reinhard Lührmann

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19 August 2017

Eric Westhof

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19 August 2017

Maria Anokhina

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19 August 2017

Sergey Bessonov

series ordinal

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19 August 2017

Klaus Hartmuth

series ordinal

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19 August 2017

language of work or name

English

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publication date

3 September 2013

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19 August 2017

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19 August 2017

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19 August 2017

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19 August 2017

2804-2818

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Crystal structure of Prp8 reveals active site cavity of the spliceosome

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Crystal structure of a group II intron in the pre-catalytic state

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Structure of the yeast U2/U6 snRNA complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Structure and assembly of the SF3a splicing factor complex of U2 snRNP

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Inclusion of weak high-resolution X-ray data for improvement of a group II intron structure

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Assemble: an interactive graphical tool to analyze and build RNA architectures at the 2D and 3D levels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Predicting and modeling RNA architecture

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Minimum-energy path for a u6 RNA conformational change involving protonation, base-pair rearrangement and base flipping

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

The ribozyme core of group II introns: a structure in want of partners

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

The spliceosome: design principles of a dynamic RNP machine

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

A critical assessment of the utility of protein-free splicing systems

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Crystal Structure of a Self-Spliced Group II Intron

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Structures of the bacterial ribosome at 3.5 A resolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Multiple functions for the invariant AGC triad of U6 snRNA.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

A catalytically active group II intron domain 5 can function in the U12-dependent spliceosome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Electrostatics of nanosystems: application to microtubules and the ribosome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Proximity of the invariant loop of U5 snRNA to the second intron residue during pre-mRNA splicing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Crystal structure of a model branchpoint-U2 snRNA duplex containing bulged adenosines

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Functional association of U2 snRNP with the ATP-independent spliceosomal complex E

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

MANIP: an interactive tool for modelling RNA.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Initial recognition of U12-dependent introns requires both U11/5' splice-site and U12/branchpoint interactions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Conserved loop I of U5 small nuclear RNA is dispensable for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Mechanical devices of the spliceosome: motors, clocks, springs, and things

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Functional analysis of the U5 snRNA loop 1 in the second catalytic step of yeast pre-mRNA splicing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

A general two-metal-ion mechanism for catalytic RNA

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Mutations in U6 snRNA that alter splice site specificity: implications for the active site

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

The splicing factor PRP2, a putative RNA helicase, interacts directly with pre-mRNA

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

The stereochemical course of group II intron self-splicing.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

The nucleotide sequence of nuclear U6 (4.7 S) RNA.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

20 June 2018

RNA splicing and genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Scanning from an independently specified branch point defines the 3' splice site of mammalian introns

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Probing the structure of RNAs in solution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

The generality of self-splicing RNA: relationship to nuclear mRNA splicing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

On the origin of RNA splicing and introns

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicingin vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

3'-Phosphatase activity in T4 polynucleotide kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Isolation of an active step I spliceosome and composition of its RNP core

20 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.198

3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.198

An unusual chemical reactivity of Sm site adenosines strongly correlates with proper assembly of core U snRNP particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.198

A structural analysis of the group II intron active site and implications for the spliceosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.198

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.198

Proximity of conserved U6 and U2 snRNA elements to the 5' splice site region in activated spliceosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.198

Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.198

U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.198

Catalytic site components common to both splicing steps of a group II intron

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.198

RNA Photolabeling Mechanistic Studies: X-ray Crystal Structure of the Photoproduct Formed between 4-Thiothymidine and Adenosine upon Near UV Irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.198

Protein docking using spherical polar Fourier correlations.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

Crosslinking of the U5 snRNP-specific 116-kDa protein to RNA hairpins that block step 2 of splicing.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817461

An RNA processing activity that debranches RNA lariats

26 November 2018

1 reference

12 December 2020

Crystallographic refinement of yeast aspartic acid transfer RNA

1 reference

12 December 2020

U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites

1 reference

12 December 2020

Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing

1 reference

12 December 2020

A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammals

1 reference

12 December 2020

The U5 and U6 small nuclear RNAs as active site components of the spliceosome

1 reference

12 December 2020

The invariant U5 snRNA loop 1 sequence is dispensable for the first catalytic step of pre-mRNA splicing in yeast

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2013.198

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

24002212

1 reference