BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability. (Q30537656)

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10 March 2020

title

BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability (English)

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10 March 2020

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10 March 2020

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10 March 2020

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10 March 2020

A Slupianek

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10 March 2020

R Falinski

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P Znojek

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S Flis

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V Doneddu

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D Pytel

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A Bellacosa

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10 March 2020

T Skorski

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10 March 2020

publication date

9 October 2012

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10 March 2020

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volume

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issue

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page(s)

629-634

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Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

10 March 2020

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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Lower phosphorylation of p38 MAPK blocks the oxidative stress-induced senescence in myeloid leukemic CD34(+)CD38 (-) cells

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23047475

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23047475

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/LEU.2012.294

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23047475%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 March 2020

0 references

1 reference

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10 March 2020

PubMed publication ID

23047475

1 reference

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