HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor (Q30459386)

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English	HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

14 August 2017

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor (English)

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Europe PubMed Central

PMC publication ID

14 August 2017

Mamuka Kvaratskhelia

11

object named as

Mamuka Kvaratskhelia

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Europe PubMed Central

14 August 2017

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Stephen H. Hughes

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object named as

Stephen H Hughes

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14 August 2017

PMC publication ID

Alan N Engelman

13

object named as

Alan Engelman

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14 August 2017

Peter Cherepanov

10

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Peter Cherepanov

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14 August 2017

author name string

Hao Wang

1

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14 August 2017

Kellie A Jurado

2

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14 August 2017

Xiaolin Wu

3

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14 August 2017

Ming-Chieh Shun

4

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14 August 2017

Xiang Li

5

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14 August 2017

Andrea L Ferris

6

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14 August 2017

Steven J Smith

7

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14 August 2017

Pratiq A Patel

8

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14 August 2017

James R Fuchs

9

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14 August 2017

language of work or name

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publication date

5 October 2012

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14 August 2017

Nucleic Acids Research

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14 August 2017

40

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14 August 2017

22

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Europe PubMed Central

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14 August 2017

11518-11530

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Europe PubMed Central

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14 August 2017

copyright license

Creative Commons Attribution-NonCommercial 3.0 Unported

4 October 2016

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April 2022 Public Data File from Crossref

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0 references

Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

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The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid.

1 reference

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20 June 2018

HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2

1 reference

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20 June 2018

Design, synthesis, and evaluation of novel 3,6-diaryl-4-aminoalkoxyquinolines as selective agonists of somatostatin receptor subtype 2.

1 reference

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20 June 2018

The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones

1 reference

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Identification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity

1 reference

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20 June 2018

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

Changes in the accessibility of the HIV-1 Integrase C-terminus in the presence of cellular proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

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A novel method for determining the inhibitory potential of anti-HIV drugs

1 reference

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Structural basis for functional tetramerization of lentiviral integrase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

The LEM domain proteins emerin and LAP2alpha are dispensable for human immunodeficiency virus type 1 and murine leukemia virus infections.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

Integrase, LEDGF/p75 and HIV replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration

1 reference

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20 June 2018

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

A gene trap knockout of the abundant sperm tail protein, outer dense fiber 2, results in preimplantation lethality

1 reference

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20 June 2018

Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

1 reference

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20 June 2018

Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations

1 reference

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20 June 2018

An essential role for LEDGF/p75 in HIV integration

1 reference

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20 June 2018

Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

1 reference

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20 June 2018

Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

20 June 2018

A role for LEDGF/p75 in targeting HIV DNA integration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

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Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

1 reference

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Genome-wide analysis of retroviral DNA integration

1 reference

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20 June 2018

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

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Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites

1 reference

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Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering

1 reference

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Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses

1 reference

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1 reference

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DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration

1 reference

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Genome-wide analyses of avian sarcoma virus integration sites

1 reference

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Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

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1 reference

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LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526291

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Early transcription from nonintegrated DNA in human immunodeficiency virus infection

1 reference

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Transcription start regions in the human genome are favored targets for MLV integration

1 reference

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12 December 2020

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10.1093/NAR/GKS913

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Europe PubMed Central

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14 August 2017

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Europe PubMed Central

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14 August 2017

PubMed publication ID

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Europe PubMed Central

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14 August 2017

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