FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75. (Q35468454)

8 August 2017

title

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75. (English)

1 reference

8 August 2017

Karin Musier-Forsyth

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Mamuka Kvaratskhelia

object named as

Mamuka Kvaratskhelia

1 reference

8 August 2017

Jacques J Kessl

1 reference

8 August 2017

Min Li

1 reference

8 August 2017

Michael Ignatov

1 reference

8 August 2017

Nikolozi Shkriabai

1 reference

8 August 2017

Jocelyn O Eidahl

1 reference

8 August 2017

Lei Feng

1 reference

8 August 2017

Robert Craigie

1 reference

8 August 2017

language of work or name

English

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publication date

19 July 2011

1 reference

8 August 2017

published in

Nucleic Acids Research

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8 August 2017

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8 August 2017

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8 August 2017

page(s)

9009-9022

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Creative Commons Attribution-NonCommercial 3.0 Unported

8 August 2017

start time

7 November 2016

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

cites work

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Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex

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27 July 2018

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Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor

27 July 2018

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A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

27 July 2018

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Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein

27 July 2018

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Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro

27 July 2018

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Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding

27 July 2018

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LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

27 July 2018

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Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

27 July 2018

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Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration

27 July 2018

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LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration

27 July 2018

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LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro

27 July 2018

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Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

27 July 2018

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Retroviral DNA integration: viral and cellular determinants of target-site selection

27 July 2018

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Discovery of a small-molecule HIV-1 integrase inhibitor-binding site

27 July 2018

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Retroviral DNA integration: reaction pathway and critical intermediates

27 July 2018

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Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

27 July 2018

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A role for LEDGF/p75 in targeting HIV DNA integration

27 July 2018

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27 July 2018

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Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

27 July 2018

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Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

27 July 2018

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Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering

27 July 2018

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27 July 2018

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Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase

27 July 2018

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Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

27 July 2018

1 reference

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LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

27 July 2018

1 reference

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Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors

27 July 2018

1 reference

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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Coupled integration of human immunodeficiency virus type 1 cDNA ends by purified integrase in vitro: stimulation by the viral nucleocapsid protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Activity of recombinant HIV-1 integrase on mini-HIV DNA.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

The barrier-to-autointegration protein is a host factor for HIV type 1 integration

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Solution structure of the N-terminal zinc binding domain of HIV-1 integrase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitro

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Monoclonal antibodies against human immunodeficiency virus type 1 integrase: epitope mapping and differential effects on integrase activities in vitro

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Characterization of human immunodeficiency virus type 1 integrase expressed in Escherichia coli and analysis of variants with amino-terminal mutations.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Protection of retroviral DNA from autointegration: involvement of a cellular factor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Solution structure of the DNA binding domain of HIV-1 integrase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

The DNA-binding domain of HIV-1 integrase has an SH3-like fold

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Integration of human immunodeficiency virus type 1 DNA in vitro

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

DNA binding properties of the integrase proteins of human immunodeficiency viruses types 1 and 2

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Time-resolved fluorescence resonance energy transfer study shows a compact denatured state of the B domain of protein A.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

An essential role for LEDGF/p75 in HIV integration

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Human immunodeficiency virus type 1 nucleocapsid zn(2+) fingers are required for efficient reverse transcription, initial integration processes, and protection of newly synthesized viral DNA.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Disulfide-linked integrase oligomers involving C280 residues are formed in vitro and in vivo but are not essential for human immunodeficiency virus replication

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

A previously unidentified host protein protects retroviral DNA from autointegration

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

Multimerization determinants reside in both the catalytic core and C terminus of avian sarcoma virus integrase

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3203615

A soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21771857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKR581

1 reference

8 August 2017

1 reference

8 August 2017

1 reference