Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators (Q39933616)

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scientific article published on October 2008

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English	Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators	scientific article published on October 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators (English)

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

1

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

author name string

Xinyu Cao

2

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Hu Zhu

3

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Francis Ali-Osman

4

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

language of work or name

0 references

publication date

1 October 2008

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Clinical Cancer Research

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

14

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

19

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

6042-6054

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression

1 reference

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Down-regulation of Stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer.

1 reference

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Lessons learned in the development of targeted therapy for malignant gliomas.

1 reference

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The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications

1 reference

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Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications

1 reference

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Stat3 activation in human endometrial and cervical cancers

1 reference

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A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo

1 reference

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Recent advances in the treatment of malignant astrocytoma

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Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

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A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

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Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer.

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Current management of glioblastoma multiforme

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The STATs of cancer--new molecular targets come of age

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Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK+ and ALK- anaplastic large cell lymphoma

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Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells

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22 September 2017

Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis

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Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice

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22 September 2017

Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells

1 reference

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22 September 2017

Opposite regulation of myc and p21waf1 transcription by STAT3 proteins

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22 September 2017

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

1 reference

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22 September 2017

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

1 reference

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STAT proteins: novel molecular targets for cancer drug discovery

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Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

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The developmental biology of brain tumors.

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From PTK-STAT signaling to caspase expression and apoptosis induction

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Stat3 as an oncogene

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Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

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Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification

1 reference

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Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

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A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors

1 reference

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Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails

1 reference

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Structural alterations of the epidermal growth factor receptor gene in human gliomas

1 reference

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1 reference

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1 reference

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Activation of stat3 and stat1 DNA binding and transcriptional activity in human brain tumour cell lines by gp130 cytokines

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https://pubmed.ncbi.nlm.nih.gov/18829483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18829483

12 December 2020

based on heuristic

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Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18829483

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1078-0432.CCR-07-4923

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

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