STAT proteins: novel molecular targets for cancer drug discovery (Q34293579)

1 August 2017

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title

STAT proteins: novel molecular targets for cancer drug discovery (English)

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regulation of tyrosine phosphorylation of STAT protein

1 August 2017

main subject

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0042509

negative regulation of tyrosine phosphorylation of STAT protein

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0042532

positive regulation of tyrosine phosphorylation of STAT protein

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Gene Ontology release 2020-05-02

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Turkson J

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1 August 2017

Jove R

series ordinal

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1 August 2017

language of work or name

English

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publication date

1 December 2000

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

6613-6626

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How cytokines signal messages within cells

1 August 2017

cites work

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Antisense therapeutics: is it as simple as complementary base recognition?

21 January 2018

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Functional roles of STAT family proteins: lessons from knockout mice

21 January 2018

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Roles of STAT3 defined by tissue-specific gene targeting

21 January 2018

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Prolactin receptor regulates Stat5 tyrosine phosphorylation and nuclear translocation by two separate pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

A non-nucleotide-bridged DNA decoy inhibits renal epithelial nitric oxide synthase expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Three-dimensional structure of the Stat3beta homodimer bound to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Inhibitors of tyrosine kinases in the treatment of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

The role of STATs in transcriptional control and their impact on cellular function

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Stat3 activation is required for cellular transformation by v-src

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Interleukin-6-specific activation of the C/EBPdelta gene in hepatocytes is mediated by Stat3 and Sp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Activation and association of Stat3 with Src in v-Src-transformed cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

The role of STATs in myeloid differentiation and leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

A Stat3-interacting protein (StIP1) regulates cytokine signal transduction

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

JAK-STAT signaling activated by Abl oncogenes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Jak-STAT signaling induced by the v-abl oncogene

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

STATs and Gene Regulation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

A nuclear tyrosine phosphatase downregulates interferon-induced gene expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Serine phosphorylation of STATs

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Drug discovery: a historical perspective

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

A new protein containing an SH2 domain that inhibits JAK kinases

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Mechanism-based target identification and drug discovery in cancer research

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Epidermal growth factor receptor--mediated stat3 signaling blocks apoptosis in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Antisense oligonucleotides: an evolving technology for the modulation of gene expression in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Anti-inflammatory gene therapy directed at the airway epithelium

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Negative regulators of cytokine signal transduction

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

The state of the STATs: recent developments in the study of signal transduction to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Jaks and Stats in signaling by the cytokine receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Cytokine-receptor complexes as chaperones for nuclear translocation of signal transducers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Hypothesis: ligand/receptor-assisted nuclear translocation of STATs

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

STAT3 regulates the growth and immunoglobulin production of BCL(1) B cell lymphoma through control of cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

STAT3 is required for the gp130-mediated full activation of the c-myc gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

"Decoy" of androgen-responsive element induces apoptosis in LNCaP cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Protein tyrosine kinase inhibitors as novel therapeutic agents

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Serine phosphorylation and negative regulation of Stat3 by JNK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

STAT signaling in the pathogenesis and treatment of leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Stat5a is mandatory for adult mammary gland development and lactogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Direct suppression of Stat1 function during adenoviral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway .

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Expression of the JAK and STAT superfamilies in human meningiomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Preclinical and clinical pharmacology of antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Distinct STAT Structure Promotes Interaction of STAT2 with the p48 Subunit of the Interferon-α-stimulated Transcription Factor ISGF3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Structure and function of a new STAT-induced STAT inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with advanced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

STAT3 is a serine kinase target in T lymphocytes. Interleukin 2 and T cell antigen receptor signals converge upon serine 727.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Stat protein transactivation domains recruit p300/CBP through widely divergent sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Cell cycle regulation and induction of apoptosis by IL-6 variants on the multiple myeloma cell line XG-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Leukemia inhibitory factor regulates proopiomelanocortin transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

CrkL functions as a nuclear adaptor and transcriptional activator in Bcr-Abl-expressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Synergistic antitumor effects of HER2/neu antisense oligodeoxynucleotides and conventional chemotherapeutic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Pharmaceutical intervention in the JAK/STAT signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Examination of the potential functional role of conserved cysteine residues in the hormone binding domain of the human 1,25-dihydroxyvitamin D3 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Modulation of STAT signaling by STAT-interacting proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Erythropoietin can induce the expression of bcl-x(L) through Stat5 in erythropoietin-dependent progenitor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Control of myeloid differentiation and survival by Stats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

STAT signaling in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

How cells respond to interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Negative regulation of the JAK/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

The expression and regulation of STATs during 3T3-L1 adipocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Amino-terminal signal transducer and activator of transcription (STAT) domains regulate nuclear translocation and STAT deactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Stat3 activation by Src induces specific gene regulation and is required for cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Distinct mechanisms of activation of Stat1 and Stat3 by platelet-derived growth factor receptor in a cell-free system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Anticancer efficacy of the irreversible EGFr tyrosine kinase inhibitor PD 0169414 against human tumor xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Kinase activation of the non-receptor tyrosine kinase Etk/BMX alone is sufficient to transactivate STAT-mediated gene expression in salivary and lung epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Requirement of serine phosphorylation for formation of STAT-promoter complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Stat3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Roles of Protein-tyrosine Phosphatases in Stat1 -mediated Cell Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Interaction of Growth Hormone-activated STATs with SH2-containing Phosphotyrosine Phosphatase SHP-1 and Nuclear JAK2 Tyrosine Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

Recombinant antibody toxins specific for ErbB2 and EGF receptor inhibit the in vitro growth of human head and neck cancer cells and cause rapid tumor regression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

Therapeutic application of anti-growth factor receptor antibodies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

Inhibitors keep cytokines in check

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

Activation of the IL-4 STAT pathway in rheumatoid synovium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

Full oncogenic activities of v-Src are mediated by multiple signaling pathways. Ras as an essential mediator for cell survival.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

Stat3 is present in the developing and adult rat cerebellum and participates in the formation of transcription complexes binding DNA at the sis-inducible element.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

c-Src activates the DNA binding and transcriptional activity of Stat3 molecules: serine 727 is not required for transcriptional activation under certain circumstances

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

beta-Thymosins are not simple actin monomer buffering proteins. Insights from overexpression studies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204086

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204086

1 reference

Dimensions Publication ID

1 August 2017

1015007460

0 references

1 reference