The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells. (Q39820039)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19636513%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

title

The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells (English)

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3 February 2020

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3 February 2020

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3 February 2020

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3 February 2020

Sharon A Mason

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3 February 2020

Sarah-Jane Cozzi

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3 February 2020

Carly J Pierce

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publication date

28 July 2009

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Investigational New Drugs

3 February 2020

published in

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volume

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issue

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3 February 2020

page(s)

575-586

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Activation of protein kinase C triggers its ubiquitination and degradation

3 February 2020

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS10637-009-9292-Y

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10637-009-9292-Y

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10637-009-9292-Y

A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents

21 January 2018

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12 December 2020

Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF.

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12 December 2020

Transformation of mammalian cells by constitutively active MAP kinase kinase

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12 December 2020

Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells

1 reference

12 December 2020

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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12 December 2020

Hallmarks of senescence in carcinogenesis and cancer therapy

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12 December 2020

Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes.

1 reference

12 December 2020

Rapid activation and down-regulation of protein kinase C alpha in 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells

1 reference

12 December 2020

Influence of 12-O-tetradecanoylphorbol-13-acetate on proliferation and maturation of human breast carcinoma cells (MCF-7): relationship to cell cycle events.

1 reference

12 December 2020

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1 reference

12 December 2020

p16 INK4a can initiate an autonomous senescence program

1 reference

12 December 2020

DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

1 reference

12 December 2020

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

1 reference

12 December 2020

Characterization of the interaction of ingenol 3-angelate with protein kinase C.

1 reference

12 December 2020

Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death

1 reference

12 December 2020

Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1.

1 reference

12 December 2020

p21WAF1 expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells.

1 reference

12 December 2020

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1 reference

12 December 2020

High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts

1 reference

12 December 2020

The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells

1 reference

12 December 2020

Dietary cancer risk conditional cancerogens in produce of livestock fed on species of spurge (Euphorbiaceae). I. Skin irritant and tumor-promoting ingenane-type diterpene esters in E. peplus, one of several herbaceous Euphorbia species contaminating

1 reference

12 December 2020

Microarray expression profiling in melanoma reveals a BRAF mutation signature.

1 reference

12 December 2020

Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester

1 reference

12 December 2020

RIG1 inhibits the Ras/mitogen-activated protein kinase pathway by suppressing the activation of Ras.

1 reference

12 December 2020

Control of the eukaryotic cell cycle by MAP kinase signaling pathways.

1 reference

12 December 2020

Administration of a phorbol ester to patients with hematological malignancies: preliminary results from a phase I clinical trial of 12-O-tetradecanoylphorbol-13-acetate

1 reference

12 December 2020

ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.

1 reference

12 December 2020

Rb interacts with histone deacetylase to repress transcription

1 reference

12 December 2020

Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells

1 reference

12 December 2020

HOME TREATMENT OF SKIN CANCER AND SOLAR KERATOSES

1 reference

12 December 2020

Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity

1 reference

12 December 2020

Growth inhibition of human melanoma-derived cells by 12-O-tetradecanoyl phorbol 13-acetate

1 reference

12 December 2020

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

12 December 2020

Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

1 reference

12 December 2020

Retinoblastoma protein switches the E2F site from positive to negative element

1 reference

12 December 2020

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

1 reference

12 December 2020

Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway.

1 reference

12 December 2020

10.1007/S10637-009-9292-Y

Identifiers

DOI

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3 February 2020

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