Hallmarks of senescence in carcinogenesis and cancer therapy (Q35743144)

10 August 2017

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title

Hallmarks of senescence in carcinogenesis and cancer therapy (English)

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10 August 2017

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Jerry W Shay

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10 August 2017

Igor B Roninson

series ordinal

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10 August 2017

language of work or name

English

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publication date

1 April 2004

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10 August 2017

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10 August 2017

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10 August 2017

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10 August 2017

page(s)

2919-2933

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

10 August 2017

cites work

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7 January 2021

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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Strand-Specific Postreplicative Processing of Mammalian Telomeres

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Atm-deficient mice: a paradigm of ataxia telangiectasia

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7 January 2021

Pot1, the putative telomere end-binding protein in fission yeast and humans

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7 January 2021

Telomere states and cell fates

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7 January 2021

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena

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7 January 2021

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

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7 January 2021

Telomerase and the maintenance of chromosome ends

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7 January 2021

p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells

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7 January 2021

Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent

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7 January 2021

Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases

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7 January 2021

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

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7 January 2021

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

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7 January 2021

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

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7 January 2021

A human telomeric protein

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7 January 2021

Smithsonian closure plan under fire

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7 January 2021

Variability at the telomeres of the human X/Y pseudoautosomal region

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7 January 2021

Do prostatic biopsies 12 months or more after external irradiation for adenocarcinoma, Stage III, predict long-term survival?

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7 January 2021

p16 INK4a can initiate an autonomous senescence program

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7 January 2021

Protection of mammalian telomeres

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7 January 2021

Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells

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7 January 2021

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7 January 2021

A DNA damage checkpoint response in telomere-initiated senescence

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7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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7 January 2021

Immortalisation and transformation revisited

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7 January 2021

Turning telomeres off and on.

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7 January 2021

Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation

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7 January 2021

Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

The RNA component of human telomerase

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7 January 2021

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7 January 2021

Rapid induction of senescence in human cervical carcinoma cells

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7 January 2021

Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts

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7 January 2021

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

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7 January 2021

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Mammalian telomeres end in a large duplex loop

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7 January 2021

RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells

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7 January 2021

Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin

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7 January 2021

Telomeres shorten during ageing of human fibroblasts

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Telomere reduction in human colorectal carcinoma and with ageing

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7 January 2021

The serial cultivation of human diploid cell strains

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

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7 January 2021

Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells

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7 January 2021

Role of telomerase in cellular proliferation and cancer

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7 January 2021

Senescence Induced by Altered Telomere State, Not Telomere Loss

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7 January 2021

Transforming growth factor beta triggers two independent-senescence programs in cancer cells

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7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

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7 January 2021

Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53.

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7 January 2021

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

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7 January 2021

Essential role of mouse telomerase in highly proliferative organs

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7 January 2021

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

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7 January 2021

Identification of human Rap1: implications for telomere evolution

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Telomerase and chromosome end maintenance.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Reverse transcriptase motifs in the catalytic subunit of telomerase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Extended culture of mouse embryo cells without senescence: inhibition by serum.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

An alternative pathway for yeast telomere maintenance rescues est1- senescence

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Lack of replicative senescence in normal rodent glia

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Hydroxyurea induces a senescence-like change of K562 human erythroleukemia cell

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Caspase inhibition switches doxorubicin-induced apoptosis to senescence

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

INI1 expression induces cell cycle arrest and markers of senescence in malignant rhabdoid tumor cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Defects in mismatch repair promote telomerase-independent proliferation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Tumor senescence as a determinant of drug response in vivo

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

A role for both RB and p53 in the regulation of human cellular senescence

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Telomerase activity in human cancer.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

The reactivation of telomerase activity in cancer progression

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Aging. When do telomeres matter?

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Cellular senescence: mitotic clock or culture shock?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Lack of replicative senescence in cultured rat oligodendrocyte precursor cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Bcl-2 promotes premature senescence induced by oncogenic Ras.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Genetics of cellular senescence

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

TRF2 Protects Human Telomeres from End-to-End Fusions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Cellular senescence as a tumor-protection mechanism: the essential role of counting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Retinoic Acid Inhibition of Cell Cycle Progression in MCF-7 Human Breast Cancer Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207518

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.279.5349.349

Identifiers

DOI

10.1038/SJ.ONC.1207518

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10 August 2017

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