Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model. (Q39808275)

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3 April 2020

title

Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model (English)

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Multifocal motor neuropathy

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Leonard H van den Berg

object named as

Leonard H van den Berg

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Lill Eva Johansen

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Sandra Kling

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Renata Vieira de Sá

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Lotte Vlam

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Henk Karst

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R Jeroen Pasterkamp

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W Ludo van der Pol

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Wouter van Rheenen

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publication date

1 June 2016

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volume

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issue

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page(s)

71-88

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Peripheral neuropathies and anti-glycolipid antibodies

3 April 2020

cites work

1 reference

Multifocal motor neuropathy: diagnosis, pathogenesis and treatment strategies

21 January 2018

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Anti-GM1 antibodies cause complement-mediated disruption of sodium channel clusters in peripheral motor nerve fibers.

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Axonal Guillain-Barré syndrome: concepts and controversies

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Anti-ganglioside antibodies can bind peripheral nerve nodes of Ranvier and activate the complement cascade without inducing acute conduction block in vitro

21 January 2018

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IVIG blocks complement deposition mediated by anti-GM1 antibodies in multifocal motor neuropathy

21 January 2018

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Sphingolipids as receptor modulators. An overview

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Asymmetric membrane ganglioside sialidase activity specifies axonal fate.

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Lipid rafts as a membrane-organizing principle

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Role of glycolipids in lipid rafts: a view through atomistic molecular dynamics simulations with galactosylceramide

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Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

21 January 2018

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RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention

21 January 2018

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Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons

21 January 2018

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Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

21 January 2018

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Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

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A revision of the El Escorial criteria - 2015.

21 January 2018

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Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.

21 January 2018

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Accelerated high-yield generation of limb-innervating motor neurons from human stem cells

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Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

21 January 2018

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Tissue deformation spatially modulates VEGF signaling and angiogenesis

21 January 2018

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Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation

21 January 2018

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Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

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Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.

21 January 2018

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

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Interaction of cholera toxin and membrane GM1 ganglioside of small intestine

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Anti-GQ1b ganglioside antibodies mediate complement-dependent destruction of the motor nerve terminal

21 January 2018

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Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni lipooligosaccharide causes Guillain-Barre syndrome

21 January 2018

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Ganglioside function in calcium homeostasis and signaling

21 January 2018

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Ganglioside complexes as new target antigens in Guillain-Barré syndrome

21 January 2018

1 reference

Sensitivity and predictive value of anti-GM1/galactocerebroside IgM antibodies in multifocal motor neuropathy

21 January 2018

1 reference

Improving the detection of IgM antibodies against glycolipids complexes of GM1 and Galactocerebroside in Multifocal Motor Neuropathy using glycoarray and ELISA assays.

21 January 2018

1 reference

N-acetylgalactosaminyl GD1a is a target molecule for serum antibody in Guillain-Barré syndrome

21 January 2018

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Antibodies against gangliosides and ganglioside complexes in Guillain-Barré syndrome: new aspects of research

21 January 2018

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Glycolipid antigens and autoantibodies in autoimmune neuropathies

21 January 2018

1 reference

The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice.

21 January 2018

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Monoclonal antibodies raised against Guillain-Barré syndrome-associated Campylobacter jejuni lipopolysaccharides react with neuronal gangliosides and paralyze muscle-nerve preparations.

21 January 2018

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Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model.

21 January 2018

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Immunoglobulins inhibit pathophysiological effects of anti-GQ1b-positive sera at motor nerve terminals through inhibition of antibody binding

21 January 2018

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Anti-GD1a antibodies activate complement and calpain to injure distal motor nodes of Ranvier in mice

21 January 2018

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Anti-ganglioside antibody internalization attenuates motor nerve terminal injury in a mouse model of acute motor axonal neuropathy.

21 January 2018

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Induction of calcium influx through TRPC5 channels by cross-linking of GM1 ganglioside associated with alpha5beta1 integrin initiates neurite outgrowth.

21 January 2018

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Human neural crest stem cells derived from human ESCs and induced pluripotent stem cells: induction, maintenance, and differentiation into functional schwann cells.

21 January 2018

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Pluripotent stem cells for Schwann cell engineering

21 January 2018

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Axon loss is an important determinant of weakness in multifocal motor neuropathy

21 January 2018

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Localization of major gangliosides in the PNS: implications for immune neuropathies

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANA.24680

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3 April 2020

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