RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention (Q24562489)

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Bryan J Traynor

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Rita Sattler

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Rita Sattler

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author name string

Christopher J Donnelly

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Ping-Wu Zhang

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Jacqueline T Pham

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Aaron R Haeusler

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Aaron R Heusler

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Nipun A Mistry

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Svetlana Vidensky

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Elizabeth L Daley

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Erin M Poth

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Benjamin Hoover

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Daniel M Fines

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Nicholas Maragakis

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Pentti J Tienari

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Jiou Wang

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Frank Rigo

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C Frank Bennett

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Jeffrey D Rothstein

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language of work or name

English

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publication date

16 October 2013

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415-28

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1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4098943/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS

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A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

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Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

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Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia.

27 September 2017

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Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration

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The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells.

27 September 2017

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Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098943

C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098943

Determination of the time course and extent of neurotoxicity at defined temperatures in cultured neurons using a modified multiwell plate fluorescence scanner

30 May 2018

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Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis.

30 May 2018

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hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

28 November 2018

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A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study

28 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24139042

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NEURON.2013.10.015

1 reference

1 reference

1 reference

PubMed publication ID

24139042

1 reference