PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis (Q39653523)

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scientific article published on 20 September 2010

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English	PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis	scientific article published on 20 September 2010

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scholarly article

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Europe PubMed Central

PubMed publication ID

13 September 2017

PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis (English)

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Europe PubMed Central

PubMed publication ID

13 September 2017

apoptotic process

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13 September 2017

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R Kappler

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A Bender

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13 September 2017

D Opel

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13 September 2017

I Naumann

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13 September 2017

L Friedman

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13 September 2017

D von Schweinitz

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13 September 2017

K-M Debatin

7

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13 September 2017

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20 September 2010

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13 September 2017

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13 September 2017

30

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4

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494-503

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13 September 2017

The Bcl-2 apoptotic switch in cancer development and therapy

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The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells

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Sensitization of neuroblastoma cells for TRAIL-induced apoptosis by NF-kappaB inhibition

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A system for stable expression of short interfering RNAs in mammalian cells

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Oncogenic mutations of ALK kinase in neuroblastoma

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Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia

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21 January 2018

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.429

21 January 2018

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

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21 January 2018

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

1 reference

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Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

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E1A activates transcription of p73 and Noxa to induce apoptosis

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21 January 2018

The PI3K/Akt/mTOR pathway as therapeutic target in neuroblastoma

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21 January 2018

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

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Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

1 reference

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Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma

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21 January 2018

Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.

1 reference

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21 January 2018

Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

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21 January 2018

The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.429

21 January 2018

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

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https://api.crossref.org/works/10.1038%2FONC.2010.429

21 January 2018

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.429

21 January 2018

Targeting the phosphoinositide 3-kinase pathway in cancer

1 reference

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21 January 2018

1 reference

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21 January 2018

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

1 reference

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21 January 2018

Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.429

21 January 2018

FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.429

21 January 2018

Activation of Akt predicts poor outcome in neuroblastoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.429

21 January 2018

Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function

1 reference

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21 January 2018

Ras, PI(3)K and mTOR signalling controls tumour cell growth

1 reference

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21 January 2018

Potentiation of neuroblastoma metastasis by loss of caspase-8.

1 reference

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21 January 2018

Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells

1 reference

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21 January 2018

Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

1 reference

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21 January 2018

Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.429

21 January 2018

Unique biology of Mcl-1: therapeutic opportunities in cancer

1 reference

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21 January 2018

The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.429

21 January 2018

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.429

21 January 2018

The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.429

21 January 2018

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.429

21 January 2018

Identifiers

10.1038/ONC.2010.429

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

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