Chemical probing reveals insights into the signaling mechanism of inflammasome activation (Q39653478)

13 September 2017

title

Chemical probing reveals insights into the signaling mechanism of inflammasome activation (English)

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13 September 2017

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Yi-Nan Gong

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13 September 2017

Xiaoming Wang

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13 September 2017

Jiayi Wang

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13 September 2017

Zhenxiao Yang

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13 September 2017

Shan Li

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13 September 2017

Jieling Yang

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13 September 2017

Liping Liu

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13 September 2017

Xiaoguang Lei

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13 September 2017

Feng Shao

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13 September 2017

publication date

21 September 2010

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13 September 2017

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13 September 2017

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13 September 2017

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13 September 2017

page(s)

1289-1305

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CATERPILLERs, pyrin and hereditary immunological disorders

13 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

The inflammasomes: guardians of the body

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

TLRs and innate immunity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Pathogen recognition in the innate immune response.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Recognition and signaling by toll-like receptors.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Shared principles in NF-kappaB signaling

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Regulation and function of NF-kappaB transcription factors in the immune system

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme

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https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

NOD-like receptors (NLRs): bona fide intracellular microbial sensors

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

NLRs at the intersection of cell death and immunity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Cryopyrin activates the inflammasome in response to toxins and ATP

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

The Nalp3 inflammasome is essential for the development of silicosis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Gout-associated uric acid crystals activate the NALP3 inflammasome

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

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https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Pseudomonas aeruginosa activates caspase 1 through Ipaf

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages

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https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Total synthesis and structure assignment of (+)-hexacyclinol.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Total synthesis of the ubiquitin-activating enzyme inhibitor (+)-panepophenanthrin

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Novel Inhibitors of Cytokine-induced IκBα Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

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https://api.crossref.org/works/10.1038%2FCR.2010.135

7 January 2021

Identifiers

DOI

10.1038/CR.2010.135

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13 September 2017

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