Alternative and aberrant splicing of MDM2 mRNA in human cancer (Q34768629)

4 August 2017

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title

Alternative and aberrant splicing of MDM2 mRNA in human cancer (English)

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4 August 2017

Helge Taubert

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Frank Bartel

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4 August 2017

Linda C Harris

series ordinal

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4 August 2017

publication date

1 July 2002

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4 August 2017

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

9-15

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The contribution of the acidic domain of MDM2 to p53 and MDM2 stability

4 August 2017

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Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

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Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma

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Novel mdm2 splice variants identified in pediatric rhabdomyosarcoma tumors and cell lines

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The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2

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Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila.

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Functions of the MDM2 oncoprotein

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Overexpression of MDM2 in acute childhood lymphoblastic leukemia

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Physical and functional interaction between wild-type p53 and mdm2 proteins

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MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation

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7 January 2021

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

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7 January 2021

Alternatively spliced MDM2 transcripts in human breast cancer in relation to tumor necrosis and lymph node involvement.

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7 January 2021

Mdm2 promotes the rapid degradation of p53

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Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

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7 January 2021

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

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7 January 2021

Expression of alternatively spliced mdm2 transcripts correlates with stabilized wild-type p53 protein in human glioblastoma cells

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7 January 2021

Regulation of p53 stability by Mdm2

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7 January 2021

Loss of MDM2 expression in human head and neck squamous cell carcinomas and clinical significance

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7 January 2021

The MDM2 gene amplification database

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7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

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7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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7 January 2021

Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes

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7 January 2021

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7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

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7 January 2021

Mdm2: keeping p53 under control

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7 January 2021

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Genetic analysis of the human oncoprotein MDM2 in benign and malignant tumors of the salivary gland

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7 January 2021

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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7 January 2021

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

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7 January 2021

Analysis of the molecular species generated by mdm2 gene amplification in liposarcomas

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7 January 2021

A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein

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7 January 2021

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

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7 January 2021

The p53-mdm-2 autoregulatory feedback loop

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7 January 2021

High prognostic significance of Mdm2/p53 co-overexpression in soft tissue sarcomas of the extremities

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7 January 2021

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes

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7 January 2021

A functional p53-responsive intronic promoter is contained within the humanmdm2gene

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7 January 2021

Mdm2 mutant defective in binding p300 promotes ubiquitination but not degradation of p53: evidence for the role of p300 in integrating ubiquitination and proteolysis

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7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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7 January 2021

10.1016/S1535-6108(02)00091-0

Identifiers

DOI

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4 August 2017

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