Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium (Q39485497)

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English	Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium	scientific article

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scholarly article

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Europe PubMed Central

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12 September 2017

Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium (English)

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12 September 2017

Clostridium difficile

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Julian Parkhill

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12 September 2017

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Graham Rose

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Richard Stabler

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Richard A Stabler

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Michael Andrew Quail

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Michael A Quail

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Dale N Gerding

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Brendan W Wren

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Gordon Dougan

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6

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Craig Corton

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12 September 2017

Mohammed Sebaihia

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Mohammed Sebaihia

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Trevor D Lawley

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12 September 2017

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Miao He

2

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12 September 2017

Lisa Dawson

3

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12 September 2017

Melissa Martin

4

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12 September 2017

Esmeralda Valiente

5

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12 September 2017

Maryse Gibert

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12 September 2017

Michel R Popoff

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12 September 2017

publication date

25 September 2009

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12 September 2017

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12 September 2017

10

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R102

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12 September 2017

Campylobacter jejuni glycosylation island important in cell charge, legionaminic acid biosynthesis, and colonization of chickens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Toxin B is essential for virulence of Clostridium difficile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Genetic relatedness of Clostridium difficile isolates from various origins determined by triple-locus sequence analysis based on toxin regulatory genes tcdC, tcdR, and cdtR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Comparative analysis of BI/NAP1/027 hypervirulent strains reveals novel toxin B-encoding gene (tcdB) sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Assessing the role of p-cresol tolerance in Clostridium difficile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Clostridium difficile toxin synthesis is negatively regulated by TcdC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Velvet: algorithms for de novo short read assembly using de Bruijn graphs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Increased sporulation rate of epidemic Clostridium difficile Type 027/NAP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Increase in Clostridium difficile-related mortality rates, United States, 1999-2004.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Historical perspectives on studies of Clostridium difficile and C. difficile infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-rep

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Binary toxin production in Clostridium difficile is regulated by CdtR, a LytTR family response regulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Clostridium difficile: changing epidemiology and new treatment options

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

A homologue of the 3-oxoacyl-(acyl carrier protein) synthase III gene located in the glycosylation island of Pseudomonas syringae pv. tabaci regulates virulence factors via N-acyl homoserine lactone and fatty acid synthesis

1 reference

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12 September 2017

Comparative phylogenomics of Clostridium difficile reveals clade specificity and microevolution of hypervirulent strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Molecular analysis of Clostridium difficile PCR ribotype 027 isolates from Eastern and Western Canada

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Flagellar glycosylation - a new component of the motility repertoire?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

ACT: the Artemis Comparison Tool

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Autoinduction and signal transduction in the regulation of staphylococcal virulence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Fluoroquinolone use and Clostridium difficile-associated diarrhea.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

New types of toxin A-negative, toxin B-positive strains among Clostridium difficile isolates from Asia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficile clinical isolates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

RelE, a global inhibitor of translation, is activated during nutritional stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Artemis: sequence visualization and annotation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Phenotypic and genotypic diversity of the flagellin gene (fliC) among Clostridium difficile isolates from different serogroups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Improved microbial gene identification with GLIMMER

1 reference

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12 September 2017

Biological function of the dTDP-rhamnose synthesis pathway in Streptococcus mutans

1 reference

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12 September 2017

Dual flaA1 flaB1 mutant of Serpulina hyodysenteriae expressing periplasmic flagella is severely attenuated in a murine model of swine dysentery

1 reference

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12 September 2017

Clostridium difficile: history of its role as an enteric pathogen and the current state of knowledge about the organism

1 reference

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12 September 2017

Transferable resistance to clindamycin, erythromycin, and tetracycline in Clostridium difficile

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12 September 2017

Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

12 September 2017

Recombination between gtfB and gtfC is required for survival of a dTDP-rhamnose synthesis-deficient mutant of Streptococcus mutans in the presence of sucrose.

1 reference

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14 September 2017

A family of stability determinants in pathogenic bacteria

1 reference

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14 September 2017

A novel toxinotyping scheme and correlation of toxinotypes with serogroups of Clostridium difficile isolates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

14 September 2017

Clinical features of Clostridium difficile-associated infections and molecular characterization of strains: results of a retrospective study, 2000-2004.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

14 September 2017

Characterization of flagella of Clostridium difficile and their role in serogrouping reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

14 September 2017

Isolation and molecular size of Clostridium botulinum type C toxin

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14 September 2017

Purification of two high molecular weight toxins of Clostridium difficile which are antigenically related

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25 September 2017

ABACAS: algorithm-based automatic contiguation of assembled sequences

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15 June 2018

Annual incidence of MRSA falls in England, but C difficile continues to rise

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

15 June 2018

Motility mutants of Vibrio cholerae O1 have reduced adherence in vitro to human small intestinal epithelial cells as demonstrated by ELISA.

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15 June 2018

Ciprofloxacin and Clostridium difficile-associated diarrhoea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

15 June 2018

Infection of hamsters with historical and epidemic BI types of Clostridium difficile

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21 August 2018

gyrA mutations in fluoroquinolone-resistant Clostridium difficile PCR-027.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

21 August 2018

Fluoroquinolone use is the predominant risk factor for the development of a new strain of clostridium difficile-associated disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768977

21 August 2018

A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use.

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21 August 2018

A hospital outbreak of Clostridium difficile disease associated with isolates carrying binary toxin genes

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21 August 2018

RelE toxins from bacteria and Archaea cleave mRNAs on translating ribosomes, which are rescued by tmRNA.

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21 August 2018

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21 August 2018

The toxigenic element of Clostridium difficile strain VPI 10463.

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21 August 2018

Toxigenic status of Clostridium difficile in a large Spanish teaching hospital

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2 December 2018

Update of Clostridium difficile-associated disease due to PCR ribotype 027 in Europe

1 reference

https://pubmed.ncbi.nlm.nih.gov/19781061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of binary-toxin genes (cdtA and cdtB) among Clostridium difficile strains isolated from patients with C. difficile-associated diarrhoea (CDAD) in Poland

1 reference

https://pubmed.ncbi.nlm.nih.gov/19781061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical features of Clostridium difficile-associated diarrhoea due to binary toxin (actin-specific ADP-ribosyltransferase)-producing strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19781061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe

1 reference

https://pubmed.ncbi.nlm.nih.gov/19781061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A portrait of the geographic dissemination of the Clostridium difficile North American pulsed-field type 1 strain and the epidemiology of C. difficile-associated disease in Québec

1 reference

https://pubmed.ncbi.nlm.nih.gov/19781061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clostridium difficile toxin expression is inhibited by the novel regulator TcdC

1 reference

https://pubmed.ncbi.nlm.nih.gov/19781061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spread and Epidemiology of Clostridium difficile Polymerase Chain Reaction Ribotype 027/Toxinotype III in The Netherlands

1 reference

https://pubmed.ncbi.nlm.nih.gov/19781061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of Clostridium difficile PCR ribotype 027 in British hospitals

1 reference

https://pubmed.ncbi.nlm.nih.gov/19781061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of polymorphisms in the toxin A and B genes of Clostridium difficile

1 reference

https://pubmed.ncbi.nlm.nih.gov/19781061

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/GB-2009-10-9-R102

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Dimensions Publication ID

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

ResearchGate publication ID

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