Contributions of the 8-methoxy group of gatifloxacin to resistance selectivity, target preference, and antibacterial activity against Streptococcus pneumoniae (Q39477371)

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English	Contributions of the 8-methoxy group of gatifloxacin to resistance selectivity, target preference, and antibacterial activity against Streptococcus pneumoniae	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Contributions of the 8-methoxy group of gatifloxacin to resistance selectivity, target preference, and antibacterial activity against Streptococcus pneumoniae (English)

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Streptococcus pneumoniae

1 reference

based on heuristic

inferred from title

author name string

H Fukuda

1

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

R Kishii

2

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

M Takei

3

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

M Hosaka

4

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

language of work or name

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publication date

1 June 2001

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

full work available at URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC90527

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Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

45

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

6

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

1649-1653

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Mechanisms and frequency of resistance to premafloxacin in Staphylococcus aureus: novel mutations suggest novel drug-target interactions

1 reference

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12 September 2017

Intracellular targets of moxifloxacin: a comparison with other fluoroquinolones

1 reference

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12 September 2017

A convenient assay for estimating the possible involvement of efflux of fluoroquinolones by Streptococcus pneumoniae and Staphylococcus aureus: evidence for diminished moxifloxacin, sparfloxacin, and trovafloxacin efflux.

1 reference

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12 September 2017

Prevalence of gyrA, gyrB, parC, and parE mutations in clinical isolates of Streptococcus pneumoniae with decreased susceptibilities to different fluoroquinolones and originating from Worldwide Surveillance Studies during the 1997-1998 respiratory se

1 reference

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12 September 2017

Dual inhibitory activity of sitafloxacin (DU-6859a) against DNA gyrase and topoisomerase IV of Streptococcus pneumoniae

1 reference

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12 September 2017

Gatifloxacin activity against quinolone-resistant gyrase: allele-specific enhancement of bacteriostatic and bactericidal activities by the C-8-methoxy group

1 reference

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12 September 2017

Streptococcus pneumoniae DNA gyrase and topoisomerase IV: overexpression, purification, and differential inhibition by fluoroquinolones

1 reference

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12 September 2017

Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine.

1 reference

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12 September 2017

Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages

1 reference

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Primary targets of fluoroquinolones in Streptococcus pneumoniae.

1 reference

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12 September 2017

ParC and GyrA may be interchangeable initial targets of some fluoroquinolones in Streptococcus pneumoniae

1 reference

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12 September 2017

Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae.

1 reference

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12 September 2017

Fluoroquinolone action against mycobacteria: effects of C-8 substituents on growth, survival, and resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90527

12 September 2017

Antibacterial activities and inhibitory effects of sitafloxacin (DU-6859a) and its optical isomers against type II topoisomerases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90527

12 September 2017

DNA topoisomerase targets of the fluoroquinolones: A strategy for avoiding bacterial resistance

1 reference

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12 September 2017

High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA.

1 reference

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12 September 2017

Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90527

12 September 2017

In vitro activity of BAY 12-8039, a new fluoroquinolone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90527

12 September 2017

Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90527

12 September 2017

Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90527

12 September 2017

In vitro and in vivo antibacterial activities of AT-4140, a new broad-spectrum quinolone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90527

12 September 2017

Comparative in vitro activity of a new quinolone, AM-1091

1 reference

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In vitro and in vivo antibacterial activities of levofloxacin (l-ofloxacin), an optically active ofloxacin

1 reference

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In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinolone

1 reference

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12 September 2017

Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase

1 reference

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12 September 2017

DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae.

1 reference

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14 September 2017

Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus

1 reference

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Molecular characterization of the gene encoding the DNA gyrase A subunit of Streptococcus pneumoniae

1 reference

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Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones

1 reference

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14 September 2017

Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones.

1 reference

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Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae.

1 reference

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ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype

1 reference

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Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance

1 reference

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Evaluation of OPC-17116 against important pathogens that cause respiratory tract infections

1 reference

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Improved bactericidal activity of Q-35 against quinolone-resistant staphylococci

1 reference

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Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli

1 reference

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Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli

1 reference

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In vitro antimicrobial activity of gatifloxacin against 873 clinical isolates from respiratory tract, urinary tract and surgical infections during 1997-1998 in Japan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=90527

21 August 2018

Identifiers

10.1128/AAC.45.6.1649-1653.2001

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

ResearchGate publication ID

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