DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. (Q39559340)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9797208%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

title

DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9797208%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

main subject

Streptococcus pneumoniae

1 reference

X S Pan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9797208%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

L M Fisher

series ordinal

1 reference

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6 December 2019

language of work or name

English

0 references

publication date

1 November 1998

1 reference

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Antimicrobial Agents and Chemotherapy

6 December 2019

published in

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6 December 2019

volume

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6 December 2019

issue

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6 December 2019

page(s)

2810-2816

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Mutations in Topoisomerase IV and DNA Gyrase of Staphylococcus aureus : Novel Pleiotropic Effects on Quinolone and Coumarin Activity

6 December 2019

cites work

1 reference

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DNA topoisomerase targets of the fluoroquinolones: A strategy for avoiding bacterial resistance

14 September 2017

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DNA gyrase, topoisomerase IV, and the 4-quinolones

14 September 2017

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Crystal structure of the breakage-reunion domain of DNA gyrase

14 September 2017

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Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae

14 September 2017

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High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA.

14 September 2017

1 reference

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Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro

14 September 2017

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Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro

14 September 2017

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Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli.

14 September 2017

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Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus.

14 September 2017

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14 September 2017

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Inducible NorA-mediated multidrug resistance in Staphylococcus aureus

14 September 2017

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Structure and mechanism of DNA topoisomerase II

14 September 2017

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Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome

14 September 2017

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Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli

14 September 2017

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Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones.

14 September 2017

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Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity

14 September 2017

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DNA sequencing with chain-terminating inhibitors

14 September 2017

1 reference

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DNA gyrase: an enzyme that introduces superhelical turns into DNA

14 September 2017

1 reference

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Quinolone susceptibility of norA-disrupted Staphylococcus aureus

14 September 2017

1 reference

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Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae

14 September 2017

1 reference

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Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones.

14 September 2017

1 reference

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Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae.

14 September 2017

1 reference

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ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=105948

Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=105948

A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex

14 September 2017

1 reference

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DNA gyrase action involves the introduction of transient double-strand breaks into DNA

14 September 2017

1 reference

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Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli

14 September 2017

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Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli

14 September 2017

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14 September 2017

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The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication

17 June 2018

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Analysis of yeast DNA topoisomerase II mutants resistant to the antitumor drug amsacrine.

17 June 2018

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Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones

21 August 2018

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The prevalence of drug-resistant Streptococcus pneumoniae in Atlanta

21 August 2018

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Resistance to penicillin and cephalosporin and mortality from severe pneumococcal pneumonia in Barcelona, Spain.

21 August 2018

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A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimurium

21 August 2018

1 reference

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Community-acquired pneumonia

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9797208

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of Yeast DNA Topoisomerase II Mutants Resistant to the Antitumor Drug Doxorubicin: Implications for the Mechanisms of Doxorubicin Action and Cytotoxicity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9797208

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.42.11.2810

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9797208%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9797208%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

PubMed publication ID

9797208

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9797208%20AND%20SRC:MED&resulttype=core&format=json