Delta-like ligand 4-notch blockade and tumor radiation response (Q39456092)

12 September 2017

title

Delta-like ligand 4-notch blockade and tumor radiation response (English)

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12 September 2017

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12 September 2017

Emmanouil Fokas

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12 September 2017

Stanley K Liu

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12 September 2017

Saif A S Bham

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12 September 2017

John Beech

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12 September 2017

Jaehong Im

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12 September 2017

Song Cho

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12 September 2017

Ruth J Muschel

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12 September 2017

language of work or name

English

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publication date

18 October 2011

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Journal of the National Cancer Institute

12 September 2017

published in

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12 September 2017

volume

103

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12 September 2017

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12 September 2017

page(s)

1778-1798

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Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies.

12 September 2017

cites work

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Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

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The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

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Notch signaling from tumor cells: a new mechanism of angiogenesis

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Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

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DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

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The canonical Notch signaling pathway: unfolding the activation mechanism

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Dosage-sensitive requirement for mouse Dll4 in artery development

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Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function

21 January 2018

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Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer

21 January 2018

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Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer

21 January 2018

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Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis

21 January 2018

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Aberrant activation of notch signaling in human breast cancer

21 January 2018

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Notch signaling in mammary development and oncogenesis

21 January 2018

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High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

21 January 2018

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NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer

21 January 2018

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The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation

21 January 2018

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Ionizing radiation shifts the PAI-1/ID-1 balance and activates notch signaling in endothelial cells

21 January 2018

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Radiotherapy suppresses angiogenesis in mice through TGF-betaRI/ALK5-dependent inhibition of endothelial cell sprouting

21 January 2018

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Impact of stromal sensitivity on radiation response of tumors.

21 January 2018

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DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs

21 January 2018

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Chronic suppression of angiogenesis following radiation exposure is independent of hematopoietic reconstitution

21 January 2018

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Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

21 January 2018

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Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells

21 January 2018

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Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

21 January 2018

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p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

21 January 2018

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Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate

21 January 2018

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Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells

21 January 2018

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21 January 2018

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Endostatin improves radioresponse and blocks tumor revascularization after radiation therapy for A431 xenografts in mice

21 January 2018

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Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells.

21 January 2018

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Preferential action of arsenic trioxide in solid-tumor microenvironment enhances radiation therapy

21 January 2018

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Statistical inference for tumor growth inhibition T/C ratio

21 January 2018

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Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix.

21 January 2018

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Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma.

21 January 2018

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Semiquantitative immunohistochemical analysis for hypoxia in human tumors

21 January 2018

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

21 January 2018

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Inhibition of gamma-secretase affects proliferation of leukemia and hepatoma cell lines through Notch signaling

21 January 2018

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Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

21 January 2018

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Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells

21 January 2018

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Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity

21 January 2018

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Predicting response to radioimmunotherapy from the tumor microenvironment of colorectal carcinomas

21 January 2018

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Three-dimensional analysis of tumour vascular corrosion casts using stereoimaging and micro-computed tomography

21 January 2018

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DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo

21 January 2018

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Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

21 January 2018

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Mechanisms of endothelial dysfunction after ionized radiation: selective impairment of the nitric oxide component of endothelium-dependent vasodilation

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Vitamin C prevents radiation-induced endothelium-dependent vasomotor dysfunction and de-endothelialization by inhibiting oxidative damage in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Delta-like 4 induces notch signaling in macrophages: implications for inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Contributions of human tumor xenografts to anticancer drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

A perivascular niche for brain tumor stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Glioblastoma stem-like cells give rise to tumour endothelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

High human IgG levels in severe combined immunodeficient mouse reconstituted with human splenic tissues from patients with gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Therapeutic antibody targeting of individual Notch receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

An immunohistochemical assessment of hypoxia in prostate carcinoma using pimonidazole: Implications for radioresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

Tumor angiogenesis in node-negative breast carcinomas ? relationship with epidermal growth factor receptor, estrogen receptor, and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJR419

21 January 2018

Identifiers

DOI

10.1093/JNCI/DJR419

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12 September 2017

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