Notch signaling in mammary development and oncogenesis (Q35858248)

12 December 2020

NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa

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12 December 2020

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

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12 December 2020

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

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12 December 2020

Diversifying neural cells through order of birth and asymmetry of division

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12 December 2020

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

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12 December 2020

Constitutive expression of a truncated INT3 gene in mouse mammary epithelium impairs differentiation and functional development

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12 December 2020

The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch

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12 December 2020

Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye.

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12 December 2020

Development. Endothelium--chicken soup for the endoderm.

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12 December 2020

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

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12 December 2020

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

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12 December 2020

Nrarp is a novel intracellular component of the Notch signaling pathway

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12 December 2020

Defects in somite formation in lunatic fringe-deficient mice

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12 December 2020

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

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12 December 2020

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

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12 December 2020

Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development.

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12 December 2020

Notch activation suppresses fibroblast growth factor-dependent cellular transformation

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12 December 2020

Notch signaling during vascular development

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12 December 2020

Role of MADS box proteins and their cofactors in combinatorial control of gene expression and cell development

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12 December 2020

Serrate2 is disrupted in the mouse limb-development mutant syndactylism

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12 December 2020

Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis.

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12 December 2020

The SLUG zinc-finger protein represses E-cadherin in breast cancer

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12 December 2020

Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia

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12 December 2020

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands

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12 December 2020

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

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12 December 2020

The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4).

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12 December 2020

Vascular remodelling during the normal and malignant life cycle of the mammary gland

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12 December 2020

Expression of an activated Notch4(int-3) oncoprotein disrupts morphogenesis and induces an invasive phenotype in mammary epithelial cells in vitro.

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12 December 2020

Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila.

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12 December 2020

Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription

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12 December 2020

Stromal effects on mammary gland development and breast cancer

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12 December 2020

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

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12 December 2020

Calcium depletion dissociates and activates heterodimeric notch receptors

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12 December 2020

Regulation of notch signaling by o-linked fucose.

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12 December 2020

Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis

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12 December 2020

Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development.

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12 December 2020

Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination

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12 December 2020

Regulation of signal transduction pathways in development by glycosylation

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12 December 2020

An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro

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12 December 2020

A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17.

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12 December 2020

The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries

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12 December 2020

Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila.

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12 December 2020

Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1

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12 December 2020

Pattern formation during C. elegans vulval induction

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12 December 2020

LIN-12/Notch signaling: lessons from worms and flies

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12 December 2020

Notch signaling in mammary gland tumorigenesis

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12 December 2020

Notching up another pathway

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12 December 2020

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

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12 December 2020

The Notch pathway helps to pattern the tips of the Drosophila tracheal branches by selecting cell fates.

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12 December 2020

Fringe is a glycosyltransferase that modifies Notch

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12 December 2020

Notch signaling: endocytosis makes delta signal better

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12 December 2020

A novel non-mouse mammary tumor virus activation of the Int-3 gene in a spontaneous mouse mammary tumor.

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12 December 2020

Twist and Notch negatively regulate adult muscle differentiation in Drosophila.

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12 December 2020

Notch: a membrane-bound transcription factor.

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12 December 2020

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium

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12 December 2020

Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm.

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12 December 2020

Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion

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12 December 2020

Echinoid facilitates Notch pathway signalling during Drosophila neurogenesis through functional interaction with Delta.

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12 December 2020

Notch and wingless regulate expression of cuticle patterning genes

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12 December 2020

HES and HERP families: multiple effectors of the Notch signaling pathway

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12 December 2020

Notch signaling: cell fate control and signal integration in development

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12 December 2020

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

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12 December 2020

Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor

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12 December 2020

Notch Receptors, Partners and Regulators: From Conserved Domains to Powerful Functions

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12 December 2020

Combinatorial signaling in the specification of unique cell fates

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12 December 2020

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

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12 December 2020

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

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12 December 2020

Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development

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12 December 2020

The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity

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12 December 2020

Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation

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12 December 2020

The function of the neurogenic genes during epithelial development in the Drosophila embryo

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12 December 2020

Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors

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12 December 2020

Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line

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12 December 2020

Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules

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12 December 2020

fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development.

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12 December 2020

Regulation of Notch signaling by a novel mechanism involving suppressor of hairless stability and carboxyl terminus-truncated notch

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12 December 2020

Furin at the cutting edge: from protein traffic to embryogenesis and disease

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12 December 2020

Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase

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12 December 2020

Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling

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12 December 2020

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway

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12 December 2020

hCDC4 gene mutations in endometrial cancer

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12 December 2020

An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling.

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12 December 2020

Intracisternal type A particle-mediated activation of the Notch4/int3 gene in a mouse mammary tumor: generation of truncated Notch4/int3 mRNAs by retroviral splicing events

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12 December 2020

Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells

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12 December 2020

Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis

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12 December 2020

Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells

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12 December 2020

Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development

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12 December 2020

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

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12 December 2020

lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor

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12 December 2020

The helix-loop-helix gene E2A is required for B cell formation

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12 December 2020

Character Changes Caused by Mutation of an Entire Region of a Chromosome in Drosophila

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12 December 2020

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

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12 December 2020

The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins

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12 December 2020

Involvement of Notch1 in the development of mouse mammary tumors

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12 December 2020

Glycosylation regulates Notch signalling.

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12 December 2020

Ras pathway signals are required for notch-mediated oncogenesis

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12 December 2020

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

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12 December 2020

Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.

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12 December 2020

Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts.

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12 December 2020

Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea.

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12 December 2020

Target specificities of Drosophila enhancer of split basic helix-loop-helix proteins

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12 December 2020

Protein degradation: four E3s for the notch pathway

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12 December 2020

Wnt3a plays a major role in the segmentation clock controlling somitogenesis

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12 December 2020

Local induction of patterning and programmed cell death in the developing Drosophila retina.

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12 December 2020

Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila

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12 December 2020

Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors.

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12 December 2020

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

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12 December 2020

Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C

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12 December 2020

Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice

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12 December 2020

Phylogenetic analysis of vertebrate and invertebrate Delta/Serrate/LAG-2 (DSL) proteins.

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12 December 2020

Chromosomal Deficiencies and the Embryonic Development of Drosophila Melanogaster

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12 December 2020

Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats

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12 December 2020

Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH.

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12 December 2020

Neoplastic transformation by Notch requires nuclear localization

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12 December 2020

Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signalling

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12 December 2020

Notch inhibition of E47 supports the existence of a novel signaling pathway

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12 December 2020

Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats

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12 December 2020

A role for pref-1 and HES-1 in thymocyte development.

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12 December 2020

lunatic fringe is an essential mediator of somite segmentation and patterning

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12 December 2020

An O-fucose site in the ligand binding domain inhibits Notch activation

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12 December 2020

F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation

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12 December 2020

Structural conservation of Notch receptors and ligands

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12 December 2020

Ligand-induced signaling in the absence of furin processing of Notch1.

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12 December 2020

Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic).

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12 December 2020

glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins

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12 December 2020

Scabrous and Gp150 are endosomal proteins that regulate Notch activity

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12 December 2020

Developmental biology. A pattern of precision.

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12 December 2020

Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex

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12 December 2020

Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling.

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12 December 2020

Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.

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12 December 2020

Processing of the notch ligand delta by the metalloprotease Kuzbanian

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12 December 2020

Analysis of notch lacking the carboxyl terminus identified in Drosophila embryos

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12 December 2020

Translational repression determines a neuronal potential in Drosophila asymmetric cell division

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12 December 2020

Clonal populations of the mouse mammary cell line, COMMA-D, which retain capability of morphogenesis in vivo.

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12 December 2020

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

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12 December 2020

Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway

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12 December 2020

Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines

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12 December 2020

The Notch1 receptor is cleaved constitutively by a furin-like convertase

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12 December 2020

Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans

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12 December 2020

Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis

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12 December 2020

Neuronal specification

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12 December 2020

Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways

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12 December 2020

Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe

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12 December 2020

Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe.

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12 December 2020

Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

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12 December 2020

The Notch locus and the cell biology of neuroblast segregation.

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12 December 2020

The notch intracellular domain can function as a coactivator for LEF-1

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12 December 2020

Prolactin regulation of beta-casein gene expression and of a cytosolic 120-kd protein in a cloned mouse mammary epithelial cell line

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12 December 2020

LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation

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12 December 2020

Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region

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12 December 2020

MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways

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12 December 2020

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

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12 December 2020

neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions

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12 December 2020

Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data

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12 December 2020

Notch responds differently to Delta and Wingless in cultured Drosophila cells

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12 December 2020

Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning

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12 December 2020