The MET oncogene transforms human primary bone-derived cells into osteosarcomas by targeting committed osteo-progenitors (Q39389679)

11 September 2017

title

The MET oncogene transforms human primary bone-derived cells into osteosarcomas by targeting committed osteo-progenitors (English)

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11 September 2017

Katia Mareschi

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Martina Olivero

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Maria Flavia Di Renzo

object named as

Maria Flavia Di Renzo

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Raffaele Calogero

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Franca Fagioli

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Silvia Miretti

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11 September 2017

Katia Scotlandi

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Nadia Dani

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11 September 2017

Marjan Maria van Duist

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11 September 2017

Sara Cuvertino

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11 September 2017

Salvatore Patané

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11 September 2017

Riccardo Ferracini

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11 September 2017

publication date

1 June 2012

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Journal of Bone and Mineral Research

11 September 2017

published in

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11 September 2017

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11 September 2017

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11 September 2017

page(s)

1322-1334

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Met, metastasis, motility and more

11 September 2017

cites work

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Scatter-factor and semaphorin receptors: cell signalling for invasive growth

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Overexpression of the hepatocyte growth factor (HGF) receptor (Met) and presence of a truncated and activated intracellular HGF receptor fragment in locally aggressive/malignant human musculoskeletal tumors.

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c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells

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A review of clinical and molecular prognostic factors in osteosarcoma

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Molecular pathogenesis of osteosarcoma.

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Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

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Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma

21 January 2018

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Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2.

21 January 2018

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Human primary bone sarcomas contain CD133+ cancer stem cells displaying high tumorigenicity in vivo.

21 January 2018

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Identification of cancer stem cells in Ewing's sarcoma

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Bone marrow mesenchymal stem cells: historical overview and concepts

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EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells

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Mesenchymal stem cell features of Ewing tumors

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Stem cells, cancer, and cancer stem cells

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Cancer stem cells in solid tumors

21 January 2018

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Concise Review: Mesenchymal Tumors: When Stem Cells Go Mad

21 January 2018

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MET overexpression turns human primary osteoblasts into osteosarcomas.

21 January 2018

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Neural differentiation of human mesenchymal stem cells: Evidence for expression of neural markers and eag K+ channel types

21 January 2018

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Stem-like cells in bone sarcomas: implications for tumorigenesis

21 January 2018

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The expression of ccn3(nov) gene in musculoskeletal tumors

21 January 2018

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Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort

21 January 2018

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Functional characterization of osteosarcoma cell lines provides representative models to study the human disease

21 January 2018

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Rb regulates fate choice and lineage commitment in vivo

21 January 2018

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Transcriptional profiling of human osteoblast differentiation

21 January 2018

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Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation

21 January 2018

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The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts

21 January 2018

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Multilineage potential of adult human mesenchymal stem cells

21 January 2018

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Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation

21 January 2018

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Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression

21 January 2018

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The effect of timing in the administration of hepatocyte growth factor to modulate BMP-2-induced osteoblast differentiation.

21 January 2018

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Fibroblast growth factor-2 induces hepatocyte growth factor/scatter factor expression in osteoblasts

21 January 2018

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Enhancement by hepatocyte growth factor of bone and cartilage formation during embryonic mouse mandibular development in vitro.

21 January 2018

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Drug development of MET inhibitors: targeting oncogene addiction and expedience

21 January 2018

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Novel therapeutic inhibitors of the c-Met signaling pathway in cancer

21 January 2018

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Efficient tumour formation by single human melanoma cells

21 January 2018

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Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines

21 January 2018

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Hierarchy revealed in the specification of three skeletal fates by Sox9 and Runx2.

21 January 2018

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Specific lineage-priming of bone marrow mesenchymal stem cells provides the molecular framework for their plasticity.

21 January 2018

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Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours

21 January 2018

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Local Mesenchymal Stem/Progenitor Cells Are a Preferential Target for Initiation of Adult Soft Tissue Sarcomas Associated with p53 and Rb Deficiency

21 January 2018

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Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

21 January 2018

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Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro.

21 January 2018

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Current concepts on the molecular biology of osteosarcoma.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JBMR.1578

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11 September 2017

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