LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein (Q39236534)

10 September 2017

LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein (English)

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10 September 2017

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Daniel F Marker

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10 September 2017

Jenna M Puccini

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10 September 2017

Taryn E Mockus

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10 September 2017

Justin Barbieri

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10 September 2017

Shao-Ming Lu

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10 September 2017

Harris A Gelbard

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10 September 2017

29 November 2012

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Journal of Neuroinflammation

10 September 2017

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10 September 2017

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10 September 2017

261

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describes a project that uses

10 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3538654/fullTextXML

inferred from PubMed Central ID database lookup

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The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

10 September 2017

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Eaten alive! Cell death by primary phagocytosis: 'phagoptosis'.

10 September 2017

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Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain

10 September 2017

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Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

10 September 2017

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(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.

10 September 2017

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Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia

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Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

10 September 2017

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LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth

10 September 2017

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LRRK2 inhibition attenuates microglial inflammatory responses

10 September 2017

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Neurocognitive dysfunction in the highly active antiretroviral therapy era.

10 September 2017

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The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

10 September 2017

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HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells

10 September 2017

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Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia

10 September 2017

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Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

10 September 2017

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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

10 September 2017

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Rac1 Protein Rescues Neurite Retraction Caused by G2019S Leucine-rich Repeat Kinase 2 (LRRK2)

10 September 2017

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Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death

10 September 2017

1 reference

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Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

10 September 2017

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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

10 September 2017

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HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

10 September 2017

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LRRK2 is involved in the IFN-gamma response and host response to pathogens

10 September 2017

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Computer control of microscopes using µManager

10 September 2017

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A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

10 September 2017

1 reference

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Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

10 September 2017

1 reference

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

10 September 2017

1 reference

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Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease

10 September 2017

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10 September 2017

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Role of Tat protein in HIV neuropathogenesis

10 September 2017

1 reference

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Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death

10 September 2017

1 reference

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Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease

10 September 2017

1 reference

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

10 September 2017

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

10 September 2017

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BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module

10 September 2017

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Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-alpha-mediated neurotoxicity

10 September 2017

1 reference

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Localization of LRRK2 to membranous and vesicular structures in mammalian brain

10 September 2017

1 reference

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538654

Phosphatidylserine recognition by phagocytes: a view to a kill

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538654

HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538654

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538654

HIV-1-associated dementia: a metabolic encephalopathy perpetrated by virus-infected and immune-competent mononuclear phagocytes.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538654

Genetic and functional heterogeneity of CNS-derived tat alleles from patients with HIV-associated dementia

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538654

HIV-1 TAT inhibits microglial phagocytosis of Abeta peptide.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538654

Cellular localization of an HIV-1 antigen in subacute AIDS encephalitis using an improved double-labeling immunohistochemical method

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538654

Cytokine expression in the brain during the acquired immunodeficiency syndrome

17 June 2018

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An immortalized cell line expresses properties of activated microglial cells

17 June 2018

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Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity.

17 June 2018

1 reference

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Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

21 August 2018

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In vivo expression of proinflammatory cytokines in HIV encephalitis: an analysis of 11 autopsy cases

21 August 2018

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Microfluidic culture platform for neuroscience research

21 August 2018

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Immunocytochemistry and quantification of protein colocalization in cultured neurons

21 August 2018

1 reference

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Apoptotic cells induce a phosphatidylserine-dependent homeostatic response from phagocytes.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538654

Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538654

Anatomical localization of leucine-rich repeat kinase 2 in mouse brain

21 August 2018

1 reference

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CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS.

21 August 2018

1 reference

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Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center

21 August 2018

1 reference

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Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia

21 August 2018

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12 December 2020

Dynamics of actin filaments in microglia during Fc receptor-mediated phagocytosis

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12 December 2020

Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images

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12 December 2020

Inflammation in Parkinson's disease

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12 December 2020

Identifiers

DOI

10.1186/1742-2094-9-261

1 reference

Dimensions Publication ID

10 September 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1742-2094-9-261

1 reference

10 September 2017

PubMed publication ID

23190742

1 reference