Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1. (Q39219980)

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English	Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

10 September 2017

Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1. (English)

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Europe PubMed Central

PubMed publication ID

10 September 2017

spinal muscular atrophy

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based on heuristic

inferred from title

muscular atrophy

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based on heuristic

inferred from title

Andreas Hoeflich

object named as

Andreas Hoeflich

7

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Klaus Viktor Toyka

8

object named as

Klaus V Toyka

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Europe PubMed Central

PubMed publication ID

10 September 2017

author name string

Frank Krieger

1

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Nicole Elflein

2

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Stefanie Saenger

3

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10 September 2017

Elisa Wirthgen

4

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Europe PubMed Central

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10 September 2017

Kristen Rak

5

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Europe PubMed Central

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10 September 2017

Stefan Frantz

6

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Friedrich Metzger

9

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10 September 2017

Sibylle Jablonka

10

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10 September 2017

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publication date

27 March 2014

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Europe PubMed Central

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10 September 2017

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Europe PubMed Central

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10 September 2017

137

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Pt 5

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10 September 2017

1374-1393

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Europe PubMed Central

PubMed publication ID

10 September 2017

Neuroprotective effect of the immune system in a mouse model of severe dysmyelinating hereditary neuropathy: enhanced axonal degeneration following disruption of the RAG-1 gene.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Increased IGF-1 in muscle modulates the phenotype of severe SMA mice

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Axonal prion protein is required for peripheral myelin maintenance

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Role of muscle insulin-like growth factors in nerve sprouting: suppression of terminal sprouting in paralyzed muscle by IGF-binding protein 4.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Free rather than total circulating insulin-like growth factor-I determines the feedback on growth hormone release in normal subjects

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Transplanted ALDHhiSSClo neural stem cells generate motor neurons and delay disease progression of nmd mice, an animal model of SMARD1.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Identification of the mouse neuromuscular degeneration gene and mapping of a second site suppressor allele

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

The natural course of infantile spinal muscular atrophy with respiratory distress type 1 (SMARD1).

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Visualization of degenerating axons in a dysmyelinating mouse mutant with axonal loss.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP

1 reference

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21 January 2018

Intraspinal cord delivery of IGF-I mediated by adeno-associated virus 2 is neuroprotective in a rat model of familial ALS.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

IGF-I deficient mice show reduced peripheral nerve conduction velocities and decreased axonal diameters and respond to exogenous IGF-I treatment

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Therapeutic potential of PEGylated insulin-like growth factor I for skeletal muscle disease evaluated in two murine models of muscular dystrophy

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Signalling pathways that mediate skeletal muscle hypertrophy and atrophy

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Alternative activation of macrophages

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Improved contractile function of the mdx dystrophic mouse diaphragm muscle after insulin-like growth factor-I administration

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Characterization of Ighmbp2 in motor neurons and implications for the pathomechanism in a mouse model of human spinal muscular atrophy with respiratory distress type 1 (SMARD1)

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Mutations in the gene encoding immunoglobulin mu-binding protein 2 cause spinal muscular atrophy with respiratory distress type 1

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Infantile spinal muscular atrophy with respiratory distress type 1 (SMARD1).

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

IGHMBP2 is a ribosome-associated helicase inactive in the neuromuscular disorder distal SMA type 1 (DSMA1)

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Clinical and mutational profile in spinal muscular atrophy with respiratory distress (SMARD): defining novel phenotypes through hierarchical cluster analysis.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Members of several gene families influence survival of rat motoneurons in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Therapeutic effects of PEGylated insulin-like growth factor I in the pmn mouse model of motoneuron disease

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Regulation and localization of ribosomal protein S6 kinase 1 isoforms

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Muscle-specific expression of insulin-like growth factor 1 improves outcome in Lama2Dy-w mice, a model for congenital muscular dystrophy type 1A

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Motor neuropathy in porphobilinogen deaminase-deficient mice imitates the peripheral neuropathy of human acute porphyria

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Macrophages recruited via CCR2 produce insulin‐like growth factor‐1 to repair acute skeletal muscle injury

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Transgenic rescue of neurogenic atrophy in the nmd mouse reveals a role for Ighmbp2 in dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Similarities between inherited demyelinating neuropathies and Wallerian degeneration: an old repair program may cause myelin and axon perturbation under nonlesion conditions

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Intramuscular administration of PEGylated IGF-I improves skeletal muscle regeneration after myotoxic injury

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Separation of fast from slow anabolism by site-specific PEGylation of insulin-like growth factor I (IGF-I).

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

IPLEX administration improves motor neuron survival and ameliorates motor functions in a severe mouse model of spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

IGF-I specifically enhances axon outgrowth of corticospinal motor neurons

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Inactivation of the IGF-I gene in mice results in perinatal lethality

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Insulinlike growth factor (IGF)-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophy

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Long-term observations of patients with infantile spinal muscular atrophy with respiratory distress type 1 (SMARD1).

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Treatment with trkC agonist antibodies delays disease progression in neuromuscular degeneration (nmd) mice

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

PEGylation enhances the therapeutic potential for insulin-like growth factor I in central nervous system disorders

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

1 reference

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21 January 2018

IGF-I and end-to-side nerve repair: a dose-response study.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Acute injury in the peripheral nervous system triggers an alternative macrophage response.

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

The neuroinflammatory role of Schwann cells in disease

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Distal infantile spinal muscular atrophy associated with paralysis of the diaphragm: A variant of infantile spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU059

21 January 2018

Identifiers

10.1093/BRAIN/AWU059

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

release_dre3hgclrbactlj6hynak2dxkq

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

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