Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation (Q39191656)

9 September 2017

Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation (English)

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9 September 2017

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9 September 2017

S Legewie

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A M M Kober

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9 September 2017

C Pforr

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9 September 2017

N Fricker

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9 September 2017

P H Krammer

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9 September 2017

I N Lavrik

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9 September 2017

6 October 2011

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9 September 2017

Cell Death and Disease

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9 September 2017

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9 September 2017

e212

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describes a project that uses

9 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3219090/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL.

1 reference

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The Fas-FADD death domain complex structure unravels signalling by receptor clustering

10 September 2017

1 reference

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Life and death in peripheral T cells

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

c-FLIPR, a new regulator of death receptor-induced apoptosis.

10 September 2017

1 reference

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Non-apoptotic Fas signaling.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Non-apoptotic signaling pathways activated by soluble Fas ligand in serum-starved human fibroblasts. Mitogen-activated protein kinases and NF-kappaB-dependent gene expression.

10 September 2017

1 reference

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The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

10 September 2017

1 reference

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The role of c-FLIP in modulation of CD95-induced apoptosis

10 September 2017

1 reference

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Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

14 September 2017

1 reference

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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

14 September 2017

1 reference

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NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2.

14 September 2017

1 reference

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Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Interdimer processing mechanism of procaspase-8 activation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

A new C-terminal cleavage product of procaspase-8, p30, defines an alternative pathway of procaspase-8 activation

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Dynamic pathway modeling: feasibility analysis and optimal experimental design

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Bistability analyses of a caspase activation model for receptor-induced apoptosis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

The active caspase-8 heterotetramer is formed at the CD95 DISC

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219090

Fas engagement induces neurite growth through ERK activation and p35 upregulation

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21975294

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The CD95 Receptor: Apoptosis Revisited

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21975294

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDDIS.2011.93

1 reference

9 September 2017

1 reference

9 September 2017

PubMed publication ID

21975294

1 reference