The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120). (Q39186814)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24860101%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120) (English)

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19 March 2020

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19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24860101%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24860101%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Graeme Milligan

1 reference

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19 March 2020

language of work or name

English

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publication date

24 May 2014

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Journal of Biological Chemistry

19 March 2020

published in

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19 March 2020

volume

289

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19 March 2020

issue

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19 March 2020

page(s)

20345-20358

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Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4

19 March 2020

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The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism

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Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

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Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors.

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10 September 2017

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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

10 September 2017

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10 September 2017

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GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

10 September 2017

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Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.

10 September 2017

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The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

10 September 2017

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Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids

10 September 2017

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Identification of residues important for agonist recognition and activation in GPR40

10 September 2017

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Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition

10 September 2017

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Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

10 September 2017

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10 September 2017

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A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets

10 September 2017

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10 September 2017

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Novel selective ligands for free fatty acid receptors GPR120 and GPR40.

14 September 2017

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Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

14 September 2017

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Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids

14 September 2017

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15 June 2018

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15 June 2018

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PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKa Predictions

21 August 2018

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4 November 2018

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Are homology models sufficiently good for free-energy simulations?

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24860101

12 December 2020

inferred from PubMed ID database lookup

Biased ligand modulation of seven transmembrane receptors (7TMRs): functional implications for drug discovery

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24860101

12 December 2020

inferred from PubMed ID database lookup

Epik: a software program for pK( a ) prediction and protonation state generation for drug-like molecules

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24860101

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M114.561449

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24860101%20AND%20SRC:MED&resulttype=core&format=json

release_kk7nncbnwrffheuhcnk32iiow4

19 March 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/kk7nncbnwrffheuhcnk32iiow4

24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24860101%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

PubMed publication ID

24860101

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24860101%20AND%20SRC:MED&resulttype=core&format=json