PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment (Q39108771)

9 September 2017

PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment (English)

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9 September 2017

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Marina Konopleva

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9 September 2017

Michael Andreeff

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9 September 2017

Teresa McQueen

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Stefan O Ciurea

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Vivian Ruvolo

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Takashi Miida

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Yoko Tabe

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Linhua Jin

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Masato Shikami

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Kensuke Kojima

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Julina Benito

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Rui-Yu Wang

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18 August 2013

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Journal of Molecular Medicine

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1383-1397

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describes a project that uses

9 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3834093/fullTextXML

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inferred from PubMed Central ID database lookup

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MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex

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The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

9 September 2017

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9 September 2017

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9 September 2017

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GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1.

9 September 2017

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Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1.

9 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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25 September 2017

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15 June 2018

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15 June 2018

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15 June 2018

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The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation

21 August 2018

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Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells.

21 August 2018

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Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins

21 August 2018

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21 August 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955073

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00109-013-1076-3

1 reference

9 September 2017

1 reference

9 September 2017

PubMed publication ID

23955073

1 reference