Substrate activity screening with kinases: discovery of small-molecule substrate-competitive c-Src inhibitors (Q38998432)

8 September 2017

Substrate activity screening with kinases: discovery of small-molecule substrate-competitive c-Src inhibitors (English)

1 reference

8 September 2017

1 reference

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2 June 2020

Michael E Steffey

1 reference

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2 June 2020

Eric J Lachacz

1 reference

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2 June 2020

Frank E Kwarcinski

1 reference

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2 June 2020

Christel C Fox

1 reference

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2 June 2020

Matthew B Soellner

1 reference

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2 June 2020

language of work or name

English

0 references

publication date

2 May 2014

1 reference

Angewandte Chemie International Edition

8 September 2017

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2 June 2020

volume

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2 June 2020

issue

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2 June 2020

page(s)

7010-7013

1 reference

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Metrics other than potency reveal systematic variation in responses to cancer drugs.

2 June 2020

cites work

1 reference

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Development of a highly selective c-Src kinase inhibitor

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

Dasatinib synergizes with both cytotoxic and signal transduction inhibitors in heterogeneous breast cancer cell lines--lessons for design of combination targeted therapy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

Comprehensive analysis of kinase inhibitor selectivity

9 September 2017

1 reference

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Tinkering Outside the Kinase ATP Box: Allosteric (Type IV) and Bivalent (Type V) Inhibitors of Protein Kinases

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

Bisubstrate inhibitors of protein kinases: from principle to practical applications

9 September 2017

1 reference

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Targeting cancer with small molecule kinase inhibitors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

Small Molecule Recognition of c-Src via the Imatinib-Binding Conformation

9 September 2017

1 reference

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Development of Src tyrosine kinase substrate binding site inhibitors

9 September 2017

1 reference

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Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi

9 September 2017

1 reference

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

9 September 2017

1 reference

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Protein kinase inhibition: different approaches to selective inhibitor design

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

Protein tyrosine kinase-substrate interactions

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

Novel procedure for modeling ligand/receptor induced fit effects.

9 September 2017

1 reference

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Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

Features of selective kinase inhibitors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

Protein kinases--the major drug targets of the twenty-first century?

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

9 September 2017

The hunting of the Src

1 reference

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Protein tyrosine kinases: structure, substrate specificity, and drug discovery

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

Cellular functions regulated by Src family kinases

9 September 2017

1 reference

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Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

Tyrosine kinase inhibition: an approach to drug development

9 September 2017

1 reference

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Criteria for analyzing interactions between biologically active agents

14 September 2017

1 reference

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Chemical influences on the specificity of tyrosine phosphorylation

14 September 2017

1 reference

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The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: a proof-of-concept study.

17 June 2018

1 reference

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ADP-Glo: A Bioluminescent and homogeneous ADP monitoring assay for kinases

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108202

A rationale for the design of an inhibitor of tyrosyl kinase

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24797781

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nonphosphorylatable tyrosine surrogates. Implications for protein kinase inhibitor design

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24797781

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/ANIE.201311096

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24797781%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24797781%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

PubMed publication ID

24797781

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24797781%20AND%20SRC:MED&resulttype=core&format=json