Genetic and epigenetic cancer chemoprevention on molecular targets during multistage carcinogenesis (Q38931011)

7 September 2017

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title

Genetic and epigenetic cancer chemoprevention on molecular targets during multistage carcinogenesis (English)

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7 September 2017

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Hyung Sik Kim

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7 September 2017

Sam Kacew

series ordinal

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7 September 2017

Byung Mu Lee

series ordinal

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7 September 2017

language of work or name

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19 August 2016

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7 September 2017

published in

Archives of Toxicology

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7 September 2017

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7 September 2017

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7 September 2017

page(s)

2389-2404

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The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor

7 September 2017

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A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells

21 January 2018

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Histone methylation modifiers in cellular signaling pathways

21 January 2018

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Resveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3-dependent pathway.

21 January 2018

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A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer

21 January 2018

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Vitamin D and Immune Response: Implications for Prostate Cancer in African Americans

21 January 2018

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Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis

21 January 2018

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Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis

21 January 2018

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The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

21 January 2018

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Digitoflavone inhibits IκBα kinase and enhances apoptosis induced by TNFα through downregulation of expression of nuclear factor κB-regulated gene products in human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Linking DNA methylation and histone modification: patterns and paradigms

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Aspirin in the Chemoprevention of Colorectal Neoplasia: An Overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Multi-targeted prevention of cancer by sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Nutrition and carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

The Keap1-Nrf2 cell defense pathway--a promising therapeutic target?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Inflammation and cancer: advances and new agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

High-dose aspirin consumption contributes to decreased risk for pancreatic cancer in a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Stage matters: choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

New insights on the anticancer properties of dietary polyphenols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Development of curcumin as an epigenetic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Replication stress and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

A critical evaluation of DNA adducts as biological markers for human exposure to polycyclic aromatic compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Antioxidative plant extracts for chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Interindividual variation among humans in carcinogen metabolism, DNA adduct formation and DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Curcumin: from ancient medicine to current clinical trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Dna adducts, mutations, and cancer 2000.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

A phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Protective effect of green tea against prostate cancer: A case‐control study in southeast China

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Resveratrol Inhibits the Invasion of Glioblastoma-Initiating Cells via Down-Regulation of the PI3K/Akt/NF-κB Signaling Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Epigenetic modifications in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Anti-inflammatory agents as cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Role for sphingosine kinase 1 in colon carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

DNA damage in cancer therapeutics: a boon or a curse?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Modulation of gene methylation by genistein or lycopene in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Dose-dependent effect of aspirin on the level of sphingolipids in human blood.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Serum lycopene concentration and prostate cancer risk: results from the Prostate Cancer Prevention Trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Effects of lycopene supplementation in patients with localized prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Platelets guide the formation of early metastatic niches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Quantitation of protein adducts as a marker of genotoxic exposure: immunologic detection of benzo[a]pyrene--globin adducts in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Resveratrol and breast cancer risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation (review).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) - study protocol for a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Anti-inflammatory phytochemicals for chemoprevention of colon cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Gene expression and biological pathways in tissue of men with prostate cancer in a randomized clinical trial of lycopene and fish oil supplementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Molecular cancer prevention: Current status and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Epigenetic targets of bioactive dietary components for cancer prevention and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Mechanisms of chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Environmental factors as regulators and effectors of multistep carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Effect of turmeric and curcumin on BP-DNA adducts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Dietary agents as histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Dihydro-β-agarofuran sesquiterpenes from celastraceae species as anti-tumour-promoting agents: Structure-activity relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Environmental Toxicant Exposure and Cancer: The Role of Epigenetic Changes and Protection by Phytochemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Insulin and insulin-like growth factor signalling in neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Cytotoxicity of dietary flavonoids on different human cancer types

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Nonsteroidal anti-inflammatory drugs diclofenac and celecoxib attenuates Wnt/β-catenin/Tcf signaling pathway in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Molecular and cellular effects of green tea on oral cells of smokers: a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Epigenetic modifications by dietary phytochemicals: implications for personalized nutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

21 January 2018

Epigenetics in cancer

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

21 January 2018

Cancer statistics, 2015

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Quercetin promotes degradation of survivin and thereby enhances death-receptor-mediated apoptosis in glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Effect of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenzo[a,l]pyrene in the human breast cells MCF-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Cancer chemoprevention: scientific promise, clinical uncertainty

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Cancer chemoprevention: a rapidly evolving field.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Chemoprevention of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Tumor necrosis factor and cancer, buddies or foes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Inhibitory effects of chlorogenic acid and its related compounds on the invasion of hepatoma cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Antioxidative and anti-carcinogenic activities of tea polyphenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-016-1813-9

10.1007/S00204-016-1813-9

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

7 September 2017

1044599285

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1 reference