Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease (Q38864016)

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scientific article published on 28 March 2017

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English	Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease	scientific article published on 28 March 2017

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instance of

scholarly article

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stated in

Europe PubMed Central

PubMed publication ID

28363773

retrieved

7 September 2017

title

Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease (English)

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stated in

Europe PubMed Central

PubMed publication ID

28363773

retrieved

7 September 2017

main subject

Alzheimer's disease

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author

Jacob M. Hooker

series ordinal

6

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stated in

Europe PubMed Central

PMC publication ID

6511375

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6511375&resulttype=core&format=json

retrieved

14 May 2020

Thor D Stein

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9

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Europe PubMed Central

PMC publication ID

6511375

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6511375&resulttype=core&format=json

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14 May 2020

author name string

Haihao Zhu

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1

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Europe PubMed Central

PMC publication ID

6511375

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6511375&resulttype=core&format=json

retrieved

14 May 2020

Xiehua Xue

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2

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PMC publication ID

6511375

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14 May 2020

Erming Wang

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3

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PMC publication ID

6511375

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Max Wallack

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4

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PMC publication ID

6511375

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Hana Na

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5

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PMC publication ID

6511375

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Neil Kowall

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7

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PMC publication ID

6511375

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Qiushan Tao

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8

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PMC publication ID

6511375

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14 May 2020

Benjamin Wolozin

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10

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PMC publication ID

6511375

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14 May 2020

Wei Qiao Qiu

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11

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PMC publication ID

6511375

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14 May 2020

publication date

28 March 2017

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Europe PubMed Central

PubMed publication ID

28363773

retrieved

7 September 2017

published in

Neuropharmacology

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Europe PubMed Central

PMC publication ID

6511375

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6511375&resulttype=core&format=json

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14 May 2020

volume

119

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Europe PubMed Central

PMC publication ID

6511375

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6511375&resulttype=core&format=json

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14 May 2020

page(s)

170-181

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Europe PubMed Central

PMC publication ID

6511375

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6511375&resulttype=core&format=json

retrieved

14 May 2020

describes a project that uses

ImageJ

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Europe PubMed Central

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11 June 2022

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https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6511375/fullTextXML

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inferred from PubMed Central ID database lookup

cites work

Effects of sequential proline substitutions on amyloid formation by human amylin20-29.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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The immunophenotype of perivascular cells in the human brain

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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Islet amyloid polypeptide in the islets of Langerhans: friend or foe?

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Quantitative neurohistological features of frontotemporal degeneration

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Cdk5: One of the links between senile plaques and neurofibrillary tangles?

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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Amylin: localization, effects on cerebral arteries and on local cerebral blood flow in the cat.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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based on heuristic

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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Central nervous system and other effects

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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G protein-coupled receptor signaling complexity in neuronal tissue: implications for novel therapeutics

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Comparison of the effects of chronic central administration and chronic peripheral administration of islet amyloid polypeptide on food intake and meal pattern in the rat.

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

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12 December 2020

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Modulating receptor function through RAMPs: can they represent drug targets in themselves?

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12 December 2020

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Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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On the Relation of Chronic Interstitial Pancreatitis to the Islands of Langerhans and to Diabetes Melutus

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Safety of pramlintide added to mealtime insulin in patients with type 1 or type 2 diabetes: a large observational study

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Enhanced amylin-mediated body weight loss in estradiol-deficient diet-induced obese rats

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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Microglial alterations in human Alzheimer's disease following Aβ42 immunization.

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Actions of β-amyloid protein on human neurons are expressed through the amylin receptor

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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The role of G protein-coupled receptors in the pathology of Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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GLP-1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Solanezumab for the treatment of mild-to-moderate Alzheimer's disease

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reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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The interaction of amylin with other hormones in the control of eating

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12 December 2020

based on heuristic

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Amylin and the regulation of appetite and adiposity: recent advances in receptor signaling, neurobiology and pharmacology

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Beta amyloid-induced depression of hippocampal long-term potentiation is mediated through the amylin receptor

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation

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reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Proteolytically inactive insulin-degrading enzyme inhibits amyloid formation yielding non-neurotoxic aβ peptide aggregates

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reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

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Amylin deposition in the brain: A second amyloid in Alzheimer disease?

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12 December 2020

based on heuristic

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A phase 3 trial of semagacestat for treatment of Alzheimer's disease

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12 December 2020

based on heuristic

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Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization

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12 December 2020

based on heuristic

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Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition.

1 reference

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging therapeutics for Alzheimer's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Janus faces of amyloid proteins in neuroinflammation

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive association between plasma amylin and cognition in a homebound elderly population

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease?

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of membrane sialoglycoproteins in exudate and resident mouse peritoneal macrophages

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https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amylin: Pharmacology, Physiology, and Clinical Potential

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amylin at the interface between metabolic and neurodegenerative disorders

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amylin-mediated control of glycemia, energy balance, and cognition

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple target of hAmylin on rat primary hippocampal neurons

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression in the Cerebral Cortex of an Alzheimer's Disease Mouse Model.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeability of the blood-brain barrier to amylin

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid-beta neurotoxicity

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amylin-induced relaxation of the perfused mesenteric arterial bed: meditation by calcitonin gene-related peptide receptors

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of AC137 (25,28,29 tripro-amylin, human) after intravenous bolus and infusion doses in patients with insulin-dependent diabetes

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma amylin immunoreactivity and insulin resistance in insulin resistant relatives of patients with non-insulin-dependent diabetes mellitus

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential permeability of the blood-brain barrier to two pancreatic peptides: insulin and amylin

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G protein-coupled receptor (GPCR) trafficking in the central nervous system: relevance for drugs of abuse

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/28363773

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12 December 2020

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Identifiers

DOI

10.1016/J.NEUROPHARM.2017.03.030

1 reference

stated in

Europe PubMed Central

PMC publication ID

6511375

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6511375&resulttype=core&format=json

retrieved

14 May 2020

PMC publication ID

6511375

1 reference

stated in

Europe PubMed Central

PMC publication ID

6511375

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6511375&resulttype=core&format=json

retrieved

14 May 2020

PubMed publication ID

28363773

1 reference

stated in

Europe PubMed Central

PMC publication ID

6511375

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6511375&resulttype=core&format=json

retrieved

14 May 2020

 

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