When DNA repair goes wrong: BER-generated DNA-protein crosslinks to oxidative lesions (Q38855612)

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scientific article published on 20 May 2016

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English	When DNA repair goes wrong: BER-generated DNA-protein crosslinks to oxidative lesions	scientific article published on 20 May 2016

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scholarly article

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Europe PubMed Central

PMC publication ID

6420214

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1 July 2019

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http://europepmc.org/abstract/PMC/6420214

review article

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Europe PubMed Central

title

When DNA repair goes wrong: BER-generated DNA-protein crosslinks to oxidative lesions (English)

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Europe PubMed Central

PMC publication ID

6420214

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1 July 2019

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http://europepmc.org/abstract/PMC/6420214

author name string

Jason Luis Quiñones

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1

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6420214

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http://europepmc.org/abstract/PMC/6420214

Bruce Demple

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2

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PMC publication ID

6420214

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1 July 2019

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http://europepmc.org/abstract/PMC/6420214

publication date

20 May 2016

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6420214

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1 July 2019

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http://europepmc.org/abstract/PMC/6420214

published in

DNA Repair

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6420214

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http://europepmc.org/abstract/PMC/6420214

volume

44

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Europe PubMed Central

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6420214

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1 July 2019

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http://europepmc.org/abstract/PMC/6420214

page(s)

103-109

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6420214

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http://europepmc.org/abstract/PMC/6420214

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2'-deoxyribonolactone lesion in DNA: refined solution structure determined by nuclear magnetic resonance and molecular modeling

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Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair

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Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues

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PubMed

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The reactivity of the 2-deoxyribonolactone lesion in single-stranded DNA and its implication in reaction mechanisms of DNA damage and repair

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Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions

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Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions

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The 7-nitroindole nucleoside as a photochemical precursor of 2'-deoxyribonolactone: access to DNA fragments containing this oxidative abasic lesion

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Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine.

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Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA

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DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis.

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The 2-deoxyribonolactone lesion produced in DNA by neocarzinostatin and other damaging agents forms cross-links with the base-excision repair enzyme endonuclease III.

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Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair

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Site-Specific Generation of Deoxyribonolactone Lesions in DNA Oligonucleotides

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Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone

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Action of human apurinic endonuclease (Ape1) on C1'-oxidized deoxyribose damage in DNA.

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Cross-linking of 2-deoxyribonolactone and its beta-elimination product by base excision repair enzymes

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DNA-protein cross-link formation mediated by oxanine. A novel genotoxic mechanism of nitric oxide-induced DNA damage

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A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair

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12 December 2020

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Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death.

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12 December 2020

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Half-life and DNA strand scission products of 2-deoxyribonolactone oxidative DNA damage lesions

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12 December 2020

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Human DNA glycosylases involved in the repair of oxidatively damaged DNA.

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12 December 2020

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Mutagenic effects of 2-deoxyribonolactone in Escherichia coli. An abasic lesion that disobeys the A-rule

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The release of 5-methylene-2-furanone from irradiated DNA catalyzed by cationic polyamines and divalent metal cations

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12 December 2020

based on heuristic

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Selective detection of 2-deoxyribonolactone in DNA.

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-patch base excision DNA repair of 2-deoxyribonolactone prevents the formation of DNA-protein cross-links with DNA polymerase beta

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and biological roles of Ape1 protein in mammalian base excision repair

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenic effects of abasic and oxidized abasic lesions in Saccharomyces cerevisiae

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of base excision DNA repair of the oxidative lesion 2-deoxyribonolactone and the formation of DNA-protein cross-links

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

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Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

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Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of DNA--protein cross-links induced by oxanine: cellular damage derived from nitric oxide and nitrous acid

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2).

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

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The chemical toxicology of 2-deoxyribose oxidation in DNA.

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12 December 2020

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Synthesis and analysis of oligonucleotides containing abasic site analogues

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1.

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PubMed

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12 December 2020

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Selective radiation-induced generation of 2-deoxyribonolactone lesions in DNA mediated by aromatic iodonium derivatives

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12 December 2020

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Biochemical evaluation of genotoxic biomarkers for 2-deoxyribonolactone-mediated cross-link formation with histones

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of the 2-deoxyribonolactone and nucleoside 5'-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass spectrometry: differential effects of gamma-radiation and Fe2+-EDTA

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apurinic/apyrimidinic (AP) site recognition by the 5′-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1)

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

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The biological and metabolic fates of endogenous DNA damage products

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

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5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

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DNA glycosylases: in DNA repair and beyond

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

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Base excision repair and cancer

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

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Molecular drug design, synthesis and crystal structure determination of CuII-SnIV heterobimetallic core: DNA binding and cleavage studies.

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12 December 2020

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A rapid and sensitive assay for DNA-protein covalent complexes in living cells

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

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Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair.

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12 December 2020

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Base excision repair: a critical player in many games

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

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Ultrasensitive isolation, identification and quantification of DNA-protein adducts by ELISA-based RADAR assay

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reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirements for 5'dRP/AP lyase activity in Ku.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of 2-deoxyribonolactone at the site of neocarzinostatin-induced cytosine release in the sequence d(AGC)

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo

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https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The current state of eukaryotic DNA base damage and repair

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https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rate of depurination of native deoxyribonucleic acid

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https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical analysis of DNA alterations. I. Base liberation and backbone breakage of DNA and oligodeoxyadenylic acid induced by hydrogen peroxide and hydroxylamine

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategic down-regulation of DNA polymerase beta by antisense RNA sensitizes mammalian cells to specific DNA damaging agents

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

1 reference

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https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abasic sites stimulate double-stranded DNA cleavage mediated by topoisomerase II. DNA lesions as endogenous topoisomerase II poisons

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repair

1 reference

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement of mammalian DNA polymerase-beta in base-excision repair.

1 reference

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two Pathways for Base Excision Repair in Mammalian Cells

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https://pubmed.ncbi.nlm.nih.gov/27264558

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I.

1 reference

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https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage induced via independent generation of the radical resulting from formal hydrogen atom abstraction from the C1'-position of a nucleotide

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian base excision repair by DNA polymerases delta and epsilon

1 reference

stated in

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reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct evidence for bimodal DNA damage induced by tirapazamine

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/27264558

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.DNAREP.2016.05.014

1 reference

stated in

Europe PubMed Central

PMC publication ID

6420214

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6420214

PMC publication ID

6420214

1 reference

stated in

Europe PubMed Central

PMC publication ID

6420214

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6420214

PubMed publication ID

27264558

1 reference

stated in

Europe PubMed Central

PMC publication ID

6420214

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6420214

 

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