Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of (R)-[11 C]verapamil in elderly vs. young subjects. (Q38841102)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28401570%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of (R)-[11 C]verapamil in elderly vs. young subjects (English)

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17 March 2020

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17 March 2020

1 reference

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17 March 2020

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Markus Alexander Zeitlinger

17 March 2020

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17 March 2020

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17 March 2020

Marcus Hacker

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17 March 2020

author name string

Beatrix Wulkersdorfer

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17 March 2020

Rudolf Karch

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17 March 2020

Walter Jäger

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17 March 2020

Johann Stanek

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17 March 2020

language of work or name

English

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publication date

4 May 2017

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British Journal of Clinical Pharmacology

17 March 2020

published in

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17 March 2020

volume

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17 March 2020

issue

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17 March 2020

page(s)

1991-1999

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Age-associated physiological and pathological changes at the blood-brain barrier: A review.

17 March 2020

cites work

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Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography

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Approaching complete inhibition of P-glycoprotein at the human blood-brain barrier: an (R)-[11C]verapamil PET study.

31 August 2018

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Activity of P-Glycoprotein, a β-Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease.

31 August 2018

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ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy.

31 August 2018

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(R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood-brain barrier, and not by MRP1 and BCRP.

31 August 2018

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P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study

31 August 2018

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31 August 2018

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Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position.

31 August 2018

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Pharmacokinetics of single ascending doses of the P-glycoprotein inhibitor tariquidar in healthy subjects

31 August 2018

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The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2).

31 August 2018

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PET imaging-based evaluation of hepatobiliary transport in humans with (15R)-11C-TIC-Me.

31 August 2018

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P-glycoprotein function at the blood-brain barrier: effects of age and gender

31 August 2018

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Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data

31 August 2018

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31 August 2018

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A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier

31 August 2018

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Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone

31 August 2018

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31 August 2018

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31 August 2018

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31 August 2018

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Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PET.

31 August 2018

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31 August 2018

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Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration

31 August 2018

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Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil

31 August 2018

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31 August 2018

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Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography

31 August 2018

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Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET.

31 August 2018

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Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

31 August 2018

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Does cerebral blood flow decline in healthy aging? A PET study with partial-volume correction.

31 August 2018

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

31 August 2018

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

31 August 2018

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

31 August 2018

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Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects

31 August 2018

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31 August 2018

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Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28401570

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/BCP.13301

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28401570%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

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17 March 2020

PubMed publication ID

28401570

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28401570%20AND%20SRC:MED&resulttype=core&format=json