Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity. (Q38808517)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

0 references

0 references

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Christian Betzel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Clemens Falker

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Alexander Hartmann

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Inga Guett

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Frank Dohler

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Dana Thurm

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Florian Wegwitz

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Pooja Joshi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

language of work or name

English

0 references

publication date

2 March 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

Journal of Neurochemistry

3 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

volume

137

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

page(s)

88-100

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

Measurement of top quark polarization in top-antitop events from proton-proton collisions at √s=7 TeV using the ATLAS detector

3 March 2020

cites work

1 reference

Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease

21 January 2018

1 reference

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

21 January 2018

1 reference

Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration.

21 January 2018

1 reference

The sheddase ADAM10 is a potent modulator of prion disease.

21 January 2018

1 reference

Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo

21 January 2018

1 reference

Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review

21 January 2018

1 reference

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

21 January 2018

1 reference

Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein

21 January 2018

1 reference

Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?

21 January 2018

1 reference

Prion protein in Alzheimer's pathogenesis: a hot and controversial issue

21 January 2018

1 reference

Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation

21 January 2018

1 reference

Prion protein and Abeta-related synaptic toxicity impairment

21 January 2018

1 reference

Effect of the E200K mutation on prion protein metabolism. Comparative study of a cell model and human brain

21 January 2018

1 reference

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

21 January 2018

1 reference

Neurotoxic amyloid beta oligomeric assemblies recreated in microfluidic platform with interstitial level of slow flow

21 January 2018

1 reference

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse

21 January 2018

1 reference

The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein.

21 January 2018

1 reference

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

21 January 2018

1 reference

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

21 January 2018

1 reference

High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease.

21 January 2018

1 reference

TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction

21 January 2018

1 reference

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo

21 January 2018

1 reference

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

21 January 2018

1 reference

Memory impairment in transgenic Alzheimer mice requires cellular prion protein

21 January 2018

1 reference

Shedding light on prion disease.

21 January 2018

1 reference

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

21 January 2018

1 reference

Upregulation of Shiga toxin receptor CD77/Gb3 and interleukin-1β expression in the brain of EHEC patients with hemolytic uremic syndrome and neurologic symptoms

21 January 2018

1 reference

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles.

21 January 2018

1 reference

Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics

21 January 2018

1 reference

The prion protein as a receptor for amyloid-beta.

21 January 2018

1 reference

Prions prevent neuronal cell-line death.

21 January 2018

1 reference

The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease

21 January 2018

1 reference

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

21 January 2018

1 reference

A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

1 reference

A simple cipher governs DNA recognition by TAL effectors

21 January 2018

1 reference

Soluble prion protein inhibits amyloid-β (Aβ) fibrillization and toxicity.

21 January 2018

1 reference

Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils

21 January 2018

1 reference

Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease

21 January 2018

1 reference

Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region

21 January 2018

1 reference

A constrained regularization method for inverting data represented by linear algebraic or integral equations

21 January 2018

1 reference

21 January 2018

1 reference

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

21 January 2018

1 reference

Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5

21 January 2018

1 reference

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

21 January 2018

1 reference

Cellular prion protein mediates toxic signaling of amyloid beta

21 January 2018

1 reference

Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1

21 January 2018

1 reference

Exosomes--vesicular carriers for intercellular communication

21 January 2018

1 reference

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

21 January 2018

1 reference

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

21 January 2018

1 reference

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

21 January 2018

1 reference

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

21 January 2018

1 reference

Up-and-down topological mode of amyloid beta-peptide lying on hydrophilic/hydrophobic interface of ganglioside clusters

21 January 2018

1 reference

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

21 January 2018

1 reference

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

Separate mechanisms act concurrently to shed and release the prion protein from the cell

21 January 2018

1 reference

The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers

21 January 2018

1 reference

Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia

21 January 2018

1 reference

Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice

21 January 2018

1 reference

A potential function for neuronal exosomes: sequestering intracerebral amyloid-β peptide.

21 January 2018

1 reference

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JNC.13514

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710111%20AND%20SRC:MED&resulttype=core&format=json