An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo (Q36685236)

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23 February 2020

title

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo (English)

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23 February 2020

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23 February 2020

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23 February 2020

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23 February 2020

Alessandra Sclip

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23 February 2020

Massimo Messa

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23 February 2020

Claudia Balducci

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23 February 2020

Brian R Fluharty

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23 February 2020

Luisa Diomede

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Pietro La Vitola

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23 February 2020

Laura Colombo

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23 February 2020

language of work or name

English

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publication date

28 January 2013

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Journal of Biological Chemistry

23 February 2020

published in

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volume

288

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issue

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page(s)

7857-7866

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Soluble prion protein inhibits amyloid-β (Aβ) fibrillization and toxicity.

23 February 2020

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1 reference

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Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

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Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

30 September 2017

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α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell death

30 September 2017

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Prion protein at the crossroads of physiology and disease.

30 September 2017

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Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death

30 September 2017

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Resolving controversies on the path to Alzheimer's therapeutics

30 September 2017

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Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice

30 September 2017

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Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

30 September 2017

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Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein

30 September 2017

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Insight into Amyloid Structure Using Chemical Probes

30 September 2017

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Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

30 September 2017

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Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse

30 September 2017

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Prion protein and Abeta-related synaptic toxicity impairment

30 September 2017

1 reference

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Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues

30 September 2017

1 reference

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Memory impairment in transgenic Alzheimer mice requires cellular prion protein

30 September 2017

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Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

30 September 2017

1 reference

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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

30 September 2017

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Isoform-specific contribution of protein kinase C to prion processing.

30 September 2017

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Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

30 September 2017

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The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein

30 September 2017

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Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor

30 September 2017

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Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans

30 September 2017

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The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

28 June 2018

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28 June 2018

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The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo

28 June 2018

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Use of surface plasmon resonance to study the elongation kinetics and the binding properties of the highly amyloidogenic Aβ(1-42) peptide, synthesized by depsi-peptide technique

28 June 2018

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Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.

5 September 2018

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Truncated forms of the human prion protein in normal brain and in prion diseases

5 September 2018

1 reference

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Thioflavin-T for Amyloid Detection

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23362282

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Human prion proteins expressed in Escherichia coli and purified by high‐affinity column refolding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23362282

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/23362282

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.423954

1 reference

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23 February 2020

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23 February 2020

PubMed publication ID

23362282

1 reference

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