Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases (Q38730494)

5 September 2017

Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases (English)

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5 September 2017

Pierre Youinou

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5 September 2017

Jacques-Olivier Pers

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5 September 2017

Yves Renaudineau

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5 September 2017

Ruby Alonso-Ramirez

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5 September 2017

Séverine Loisel

series ordinal

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5 September 2017

Caroline Buors

series ordinal

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5 September 2017

Enrique Montero

series ordinal

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5 September 2017

1 January 2010

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5 September 2017

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5 September 2017

2010

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5 September 2017

130646

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Creative Commons Attribution 3.0 Unported

5 September 2017

start time

10 February 2010

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April 2022 Public Data File from Crossref

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

6 September 2017

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The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome

6 September 2017

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6 September 2017

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CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock

6 September 2017

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Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse.

6 September 2017

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CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76

6 September 2017

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6 September 2017

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6 September 2017

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Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells

6 September 2017

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The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains

6 September 2017

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The SLP-76 family of adapter proteins

6 September 2017

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Relevance of CD6-mediated interactions in T cell activation and proliferation

6 September 2017

1 reference

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The E47 transcription factor negatively regulates CD5 expression during thymocyte development

6 September 2017

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OX52 is the rat homologue of CD6: evidence for an effector function in the regulation of CD5 phosphorylation

6 September 2017

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The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells

6 September 2017

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CD2 physically associates with CD5 in rat T lymphocytes with the involvement of both extracellular and intracellular domains

6 September 2017

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Cell surface receptors and their ligands: in vitro analysis of CD6-CD166 interactions

6 September 2017

1 reference

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HCA, an immunoglobulin-like adhesion molecule present on the earliest human hematopoietic precursor cells, is also expressed by stromal cells in blood-forming tissues

6 September 2017

1 reference

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CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

6 September 2017

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Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains.

6 September 2017

1 reference

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Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding

6 September 2017

1 reference

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Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms

6 September 2017

1 reference

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The SRCR superfamily: a family reminiscent of the Ig superfamily

6 September 2017

1 reference

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Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Identification of a mouse protein homologous to the human CD6 T cell surface protein and sequence of the corresponding cDNA

6 September 2017

1 reference

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Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells

6 September 2017

1 reference

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Reconstitution after transplantation with T-lymphocyte-depleted HLA haplotype-mismatched bone marrow for severe combined immunodeficiency

6 September 2017

1 reference

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The human CD6 gene is transcriptionally regulated by RUNX and Ets transcription factors in T cells.

6 September 2017

1 reference

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Expression and characterization of a novel CD6 ligand in cells derived from joint and epithelial tissues

14 September 2017

1 reference

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Transcriptional regulation of human CD5: important role of Ets transcription factors in CD5 expression in T cells.

14 September 2017

1 reference

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CD5 is A potential selecting ligand for B-cell surface immunoglobulin: a possible role in maintenance and selective expansion of normal and malignant B cells

14 September 2017

1 reference

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Role of the CD6 glycoprotein in antigen-specific and autoreactive responses of cloned human T lymphocytes.

25 September 2017

1 reference

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The amino-terminal immunoglobulin-like domain of activated leukocyte cell adhesion molecule binds specifically to the membrane-proximal scavenger receptor cysteine-rich domain of CD6 with a 1:1 stoichiometry

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Genomic organization of the human CD5 gene

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

An NFAT-dependent enhancer is necessary for anti-IgM-mediated induction of murine CD5 expression in primary splenic B cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Cloning and characterization of murine CD6.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Expression of the CD6 T lymphocyte differentiation antigen in normal human brain

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Cell-free CD5 in patients with rheumatic diseases

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Aberrant expression of CD6 on B-cell subsets from patients with Sjögren's syndrome

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Selection of the alternative exon 1 from the cd5 gene down-regulates membrane level of the protein in B lymphocytes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Distinct kinetic and mechanical properties govern ALCAM-mediated interactions as shown by single-molecule force spectroscopy.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Frontline: Optimal T cell activation requires the engagement of CD6 and CD166.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Humanization of Predicted T-Cell Epitopes Reduces the Immunogenicity of Chimeric Antibodies: New Evidence Supporting a Simple Method

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

CD6: expression during development, apoptosis and selection of human and mouse thymocytes.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Simultaneous cross-linking of CD6 and CD28 induces cell proliferation in resting T cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

Long-term outcomes of nonconditioned patients with severe combined immunodeficiency transplanted with HLA-identical or haploidentical bone marrow depleted of T cells with anti-CD6 mAb

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2010%2F130646

Phosphorylation-dephosphorylation of the CD6 glycoprotein renders two isoforms of 130 and 105 kilodaltons. Effect of serum and protein kinase C activators

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195340

CD6 molecule may be important in the pathological mechanisms of lymphocytes adhesion to human skin in psoriasis and ior t1 MAb a possible new approach to treat this disease

3 December 2018

1 reference

12 December 2020

Evidence for Protein Tyrosine Kinase Involvement in CD6-Induced T Cell Proliferation

1 reference

12 December 2020

Characterization of the human CD5 endogenous retrovirus-E in B lymphocytes

1 reference

12 December 2020

CD6-depleted allogeneic bone marrow transplantation for acute leukemia in first complete remission

1 reference

12 December 2020

Natural history of mixed chimerism after bone marrow transplantation with CD6-depleted allogeneic marrow: a stable equilibrium

1 reference

12 December 2020

Isolation and characterization of CD6- T cells from peripheral blood

1 reference

12 December 2020

Treatment of acute renal allograft rejection with monoclonal anti-T12 antibody

1 reference

12 December 2020

Activation of human T cells through CD6: functional effects of a novel anti-CD6 monoclonal antibody and definition of four epitopes of the CD6 glycoprotein

1 reference

12 December 2020

Structure and chromosomal localization of chicken CD5

1 reference

12 December 2020

High circulating levels of soluble scavenger receptors (sCD5 and sCD6) in patients with primary Sjögren's syndrome

1 reference

12 December 2020

Evidence for the expression of a second CD6 ligand by synovial fibroblasts

1 reference

12 December 2020

CD166 Expression, Characterization, and Localization in Salivary Epithelium: Implications for Function During Sialoadenitis

1 reference

12 December 2020

Tissue distribution of CD6 and CD6 ligand in cattle: expression of the CD6 ligand (CD166) in the autonomic nervous system of cattle and the human

1 reference

12 December 2020

Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system

1 reference

12 December 2020

CD6 ligation modulates the Bcl-2/Bax ratio and protects chronic lymphocytic leukemia B cells from apoptosis induced by anti-IgM

1 reference

12 December 2020

Molecular linkage of the mouse CD5 and CD6 genes

1 reference

12 December 2020

Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid arthritis synovium

1 reference

12 December 2020

Identifiers

DOI

10.1155/2010/130646

1 reference

5 September 2017

1 reference

5 September 2017

PubMed publication ID

22076177

1 reference