Pridopidine for the treatment of Huntington's disease (Q38735562)

6 September 2017

title

Pridopidine for the treatment of Huntington's disease (English)

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6 September 2017

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Kathleen M Shannon

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6 September 2017

language of work or name

English

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publication date

16 February 2016

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Expert Opinion on Investigational Drugs

6 September 2017

published in

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6 September 2017

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6 September 2017

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6 September 2017

page(s)

485-492

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

6 September 2017

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Triheptanoin improves brain energy metabolism in patients with Huntington disease

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Pharmacokinetics and metabolism of SRX246: a potent and selective vasopressin 1a antagonist

21 January 2018

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Analysis of the actions of the novel dopamine receptor-directed compounds (S)-OSU6162 and ACR16 at the D2 dopamine receptor

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Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington's disease

21 January 2018

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The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties

21 January 2018

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The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for mot

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Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses

21 January 2018

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Pharmacokinetic and tolerability profile of pridopidine in healthy-volunteer poor and extensive CYP2D6 metabolizers, following single and multiple dosing

21 January 2018

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Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

21 January 2018

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Efficacy and safety of the dopaminergic stabilizer Pridopidine (ACR16) in patients with Huntington's disease

21 January 2018

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Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial

21 January 2018

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One-year safety and tolerability profile of pridopidine in patients with Huntington disease

21 January 2018

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10.1517/13543784.2016.1153627

21 January 2018

Identifiers

DOI

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6 September 2017

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