Protein prenylation: unique fats make their mark on biology (Q38704283)

5 September 2017

title

Protein prenylation: unique fats make their mark on biology (English)

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5 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26790532%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26790532%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Mei Wang

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5 September 2017

Patrick J Casey

series ordinal

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5 September 2017

publication date

21 January 2016

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Nature Reviews Molecular Cell Biology

5 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26790532%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26790532%20AND%20SRC:MED&resulttype=core&format=json

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issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26790532%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

110-122

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26790532%20AND%20SRC:MED&resulttype=core&format=json

Natural expansion of the genetic code

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Reaction path of protein farnesyltransferase at atomic resolution

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Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release

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Structure of mammalian protein geranylgeranyltransferase type-I

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Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions

31 March 2020

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Peptide specificity of protein prenyltransferases is determined mainly by reactivity rather than binding affinity

31 March 2020

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Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae

31 March 2020

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GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

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Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer

31 March 2020

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Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

31 March 2020

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Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice

31 March 2020

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Role for RhoB and PRK in the suppression of epithelial cell transformation by farnesyltransferase inhibitors

31 March 2020

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Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

31 March 2020

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Splice variants of SmgGDS control small GTPase prenylation and membrane localization

31 March 2020

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The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.

31 March 2020

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An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering

31 March 2020

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Cloning and characterization of a mammalian prenyl protein-specific protease

31 March 2020

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Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells

31 March 2020

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Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing

31 March 2020

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Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

31 March 2020

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Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1

31 March 2020

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Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT

31 March 2020

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Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe

31 March 2020

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Mutational analysis of the integral membrane methyltransferase isoprenylcysteine carboxyl methyltransferase (ICMT) reveals potential substrate binding sites.

31 March 2020

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Functional oligomerization of the Saccharomyces cerevisiae isoprenylcysteine carboxyl methyltransferase, Ste14p

31 March 2020

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Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues

31 March 2020

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Topology of the yeast Ras converting enzyme as inferred from cysteine accessibility studies

31 March 2020

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Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI

31 March 2020

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Rho GTPases: biochemistry and biology

31 March 2020

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Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding

31 March 2020

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14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins

31 March 2020

1 reference

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Multiple Cellular Proteins Modulate the Dynamics of K-ras Association with the Plasma Membrane

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.11

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.11

Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization

31 March 2020

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Prenylated Rab acceptor protein is a receptor for prenylated small GTPases

31 March 2020

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RAS oncogenes: the first 30 years.

31 March 2020

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Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

The farnesyl transferase inhibitor SCH 66336 induces a G(2) --> M or G(1) pause in sensitive human tumor cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

The role of nuclear lamin B1 in cell proliferation and senescence.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.11

Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors.

31 March 2020

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The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.11

Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

31 March 2020

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Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling

31 March 2020

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Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells

31 March 2020

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A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity

31 March 2020

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Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.

31 March 2020

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In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I

31 March 2020

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The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity

31 March 2020

1 reference

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Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis

31 March 2020

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Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors

31 March 2020

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On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.

31 March 2020

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RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments

31 March 2020

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Isoprenylcysteine carboxyl methyltransferase deficiency in mice

31 March 2020

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Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.11

Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro

31 March 2020

1 reference

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A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.11

A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells

31 March 2020

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Farnesyltransferase inhibitors-induced autophagy: alternative mechanisms?

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.11

A role for Rac3 GTPase in the regulation of autophagy

31 March 2020

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mTOR: a pharmacologic target for autophagy regulation

31 March 2020

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Autophagy in aging, disease and death: the true identity of a cell death impostor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Post-translational processing of RhoA. Carboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of Rhoa

31 March 2020

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Mammalian Rho GTPases: new insights into their functions from in vivo studies

31 March 2020

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A perspective on cancer cell metastasis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.11

Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Prenylation of Rho G-proteins: a novel mechanism regulating gene expression and protein stability in human trabecular meshwork cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Control of RhoA methylation by carboxylesterase I

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.11

Liver prenylated methylated protein methyl esterase is the same enzyme as Sus scrofa carboxylesterase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Prenylcysteine methylesterase in Arabidopsis thaliana

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.11

Isoprenylcysteine methylation and demethylation regulate abscisic acid signaling in Arabidopsis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.11

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.11

Farnesyltransferase inhibitors: a detailed chemical view on an elusive biological problem

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Development of farnesyltransferase inhibitors for clinical cancer therapy: focus on hematologic malignancies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Farnesyltransferase inhibitors: where are we now?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Geranylgeranyl transferase regulates CXC chemokine formation in alveolar macrophages and neutrophil recruitment in septic lung injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Anti-inflammatory effects of statins: clinical evidence and basic mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Discovery and SAR of Methylated Tetrahydropyranyl Derivatives as Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase (ICMT)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

S-Farnesyl-Thiopropionic Acid (FTPA) Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Biochemical studies of Zmpste24-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Prelamin A farnesylation and progeroid syndromes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Nuclear lamins: laminopathies and their role in premature ageing.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Impact of farnesylation inhibitors on survival in Hutchinson-Gilford progeria syndrome.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Inhibiting geranylgeranylation increases neurite branching and differentially activates cofilin in cell bodies and growth cones

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Protein prenylation and synaptic plasticity: implications for Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

The chemical toolbox for monitoring protein fatty acylation and prenylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

A combination of metabolic labeling and 2D-DIGE analysis in response to a farnesyltransferase inhibitor facilitates the discovery of new prenylated proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Selective labeling of proteins by using protein farnesyltransferase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Isoprenoids, small GTPases and Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Statin myopathy: a review of recent progress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Geranylgeranylation but not GTP loading determines rho migratory function in T cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Metabolic control of YAP and TAZ by the mevalonate pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Development: Keeping your cell identity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Identification of a prenylation site in delta virus large antigen

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Epidemiology, pathogenesis and management of hepatitis D: update and challenges ahead

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.11

Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins

31 March 2020

1 reference

12 December 2020

Clinical review 145: Pleiotropic effects of statins: lipid reduction and beyond

1 reference

12 December 2020

Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism

1 reference

12 December 2020

Purification and properties of geranylgeranyl-diphosphate synthase from bovine brain

1 reference

12 December 2020

Roles of prenyl protein proteases in maturation of Saccharomyces cerevisiae a-factor

1 reference

12 December 2020

Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis

1 reference

12 December 2020

Metabolism: YAP and TAZ under metabolic control

1 reference

12 December 2020

Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor

1 reference

12 December 2020

The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins

1 reference

12 December 2020

Evidence for modification of lamin B by a product of mevalonic acid

1 reference

12 December 2020

The processing pathway of prelamin A

1 reference

12 December 2020

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth

1 reference

12 December 2020

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

1 reference

12 December 2020

Farnesyltransferase inhibitors as anticancer agents: critical crossroads.

1 reference

12 December 2020

Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component

1 reference

12 December 2020

cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase

1 reference

12 December 2020

Characterization of a plasma membrane-associated prenylcysteine-directed alpha carboxyl methyltransferase in human neutrophils

1 reference

12 December 2020