Anti-inflammatory effects of statins: clinical evidence and basic mechanisms (Q36337932)

13 August 2017

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title

Anti-inflammatory effects of statins: clinical evidence and basic mechanisms (English)

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13 August 2017

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Paul M Ridker

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13 August 2017

Mukesh K Jain

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13 August 2017

publication date

1 December 2005

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Nature Reviews Drug Discovery

13 August 2017

published in

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13 August 2017

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13 August 2017

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13 August 2017

page(s)

977-987

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Inflammation in atherosclerosis

13 August 2017

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HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size

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An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro

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Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization

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Inflammation and thrombosis

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Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation

21 January 2018

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The effect of statins on mRNA levels of genes related to inflammation, coagulation, and vascular constriction in HUVEC. Human umbilical vein endothelial cells

21 January 2018

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Global analysis of RNA expression profile in human vascular cells treated with statins

21 January 2018

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In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products

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Regulation of interleukin-8 expression by HMG-CoA reductase inhibitors in human vascular smooth muscle cells

21 January 2018

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Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty

21 January 2018

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Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

21 January 2018

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Simvastatin reduces neointimal thickening in low-density lipoprotein receptor-deficient mice after experimental angioplasty without changing plasma lipids

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HMG-CoA reductase inhibition improves endothelial cell function and inhibits smooth muscle cell proliferation in human saphenous veins

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Pleiotropic effects of statins

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Lung Kruppel-like factor, a zinc finger transcription factor, is essential for normal lung development

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The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis

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KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation

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Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function

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Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway

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Statins exert endothelial atheroprotective effects via the KLF2 transcription factor

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Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells

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Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I

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Rho-kinase is an important therapeutic target in cardiovascular medicine

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Expression of monocyte chemotactic protein and interleukin-8 by cytokine-activated human vascular smooth muscle cells

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Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice

31 March 2020

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HMG CoA reductase inhibitors are related to improved systemic endothelial function in coronary artery disease

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Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium

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Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans

31 March 2020

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Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month

31 March 2020

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31 March 2020

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Inhibition of monocyte chemotactic protein-1 synthesis by statins

31 March 2020

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HMG-CoA Reductase Inhibitors Decrease CD11b Expression and CD11b-Dependent Adhesion of Monocytes to Endothelium and Reduce Increased Adhesiveness of Monocytes Isolated From Patients With Hypercholesterolemia

31 March 2020

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Statins for Atherosclerosis — As Good as It Gets?

31 March 2020

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3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)

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3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Isoprenylation Inhibitors Induce Apoptosis of Vascular Smooth Muscle Cells in Culture

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A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall

31 March 2020

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Short-term atorvastatin treatment improves endothelial function in hypercholesterolemic women

31 March 2020

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HMG-CoA reductase inhibitor stabilizes rabbit atheroma by increasing basal NO and decreasing superoxide

31 March 2020

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Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors

31 March 2020

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Peroxisome proliferator-activated receptors as therapeutic targets in inflammation

31 March 2020

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LKLF: A Transcriptional Regulator of Single-Positive T Cell Quiescence and Survival

31 March 2020

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Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1901

1 reference

13 August 2017

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