Synaptic failure and α-synuclein (Q38704236)

5 September 2017

title

Synaptic failure and α-synuclein (English)

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5 September 2017

author

Maria Grazia Spillantini

series ordinal

object named as

Maria Grazia Spillantini

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5 September 2017

Laura Calo

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5 September 2017

Michal Wegrzynowicz

series ordinal

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5 September 2017

Jessica Santivañez-Perez

series ordinal

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5 September 2017

language of work or name

English

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publication date

21 January 2016

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5 September 2017

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5 September 2017

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5 September 2017

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5 September 2017

page(s)

169-177

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

5 September 2017

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α-synuclein multimers cluster synaptic vesicles and attenuate recycling

21 January 2018

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α-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis

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Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

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α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter.

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Testosterone regulates alpha-synuclein mRNA in the avian song system

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Decreased reuptake of dopamine in the dorsal striatum in the absence of α-synuclein.

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

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The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

21 January 2018

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Alpha-synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs

21 January 2018

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Impaired intracellular trafficking defines early Parkinson's disease

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The progression of pathology in longitudinally followed patients with Parkinson's disease.

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Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease.

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In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution

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Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease

21 January 2018

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In vivo demonstration that alpha-synuclein oligomers are toxic

21 January 2018

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Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

21 January 2018

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Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain

21 January 2018

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The paraffin-embedded tissue blot detects PrP(Sc) early in the incubation time in prion diseases

21 January 2018

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Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies.

21 January 2018

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Selective detection, quantification, and subcellular location of alpha-synuclein aggregates with a protein aggregate filtration assay

21 January 2018

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Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice

21 January 2018

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Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

21 January 2018

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Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo

21 January 2018

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Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease

21 January 2018

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Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution

21 January 2018

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Biochemical aspects of Parkinson's disease

21 January 2018

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A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.

21 January 2018

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Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity.

21 January 2018

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SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease

21 January 2018

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Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

21 January 2018

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21 January 2018

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Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.

21 January 2018

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Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

21 January 2018

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Monomeric synucleins generate membrane curvature

21 January 2018

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Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

21 January 2018

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Is Parkinson's disease a vesicular dopamine storage disorder? Evidence from a study in isolated synaptic vesicles of human and nonhuman primate striatum

21 January 2018

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alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease

21 January 2018

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21 January 2018

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Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease

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Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation

21 January 2018

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

21 January 2018

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

21 January 2018

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21 January 2018

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Parkinson's disease: a dual-hit hypothesis

21 January 2018

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Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

21 January 2018

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Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.

21 January 2018

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Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice

21 January 2018

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Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

21 January 2018

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Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease.

21 January 2018

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Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

21 January 2018

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Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

21 January 2018

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Caudo-rostral brain spreading of α-synuclein through vagal connections

21 January 2018

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Pathological alpha-synuclein propagates through neural networks

21 January 2018

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Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

21 January 2018

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Axonal transport defects: a common theme in neurodegenerative diseases

21 January 2018

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Axonal transport in neurological disease

21 January 2018

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Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration

21 January 2018

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Potential role of α-synuclein in neurodegeneration: studies in a rat animal model

21 January 2018

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Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease

21 January 2018

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1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C

21 January 2018

1 reference

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21 January 2018

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