Acetate as a Metabolic and Epigenetic Modifier of Cancer Therapy (Q38562373)

4 September 2017

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title

Acetate as a Metabolic and Epigenetic Modifier of Cancer Therapy (English)

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4 September 2017

Diane M Jaworski

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4 September 2017

Aryan M A Namboodiri

series ordinal

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4 September 2017

John R Moffett

series ordinal

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4 September 2017

publication date

7 August 2015

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Journal of Cellular Biochemistry

4 September 2017

published in

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4 September 2017

volume

117

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4 September 2017

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4 September 2017

page(s)

574-588

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Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism

4 September 2017

cites work

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Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain

21 January 2018

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Metabolic acetate therapy for the treatment of traumatic brain injury.

21 January 2018

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Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease

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Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

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Triacetin: a potential parenteral nutrient

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Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis

21 January 2018

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Acetate supplementation reduces microglia activation and brain interleukin-1β levels in a rat model of Lyme neuroborreliosis

21 January 2018

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Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes.

21 January 2018

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The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment

21 January 2018

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Lysine acetylation targets protein complexes and co-regulates major cellular functions

21 January 2018

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Acetate dependence of tumors

21 January 2018

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The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation

21 January 2018

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Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan

21 January 2018

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Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux

21 January 2018

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Sirtuin catalysis and regulation

21 January 2018

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Fatty acid synthase as a potential therapeutic target in cancer

21 January 2018

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

21 January 2018

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Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate

21 January 2018

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Metabolic targets for cancer therapy

21 January 2018

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Metformin, an old drug, brings a new era to cancer therapy

21 January 2018

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SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism

21 January 2018

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Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity.

21 January 2018

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A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases

21 January 2018

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Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate.

21 January 2018

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Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts

21 January 2018

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Otto Warburg's contributions to current concepts of cancer metabolism

21 January 2018

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Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth

21 January 2018

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N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells

21 January 2018

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Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest

21 January 2018

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Acetate supplementation induces growth arrest of NG2/PDGFRα-positive oligodendroglioma-derived tumor-initiating cells

21 January 2018

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Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins

21 January 2018

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The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

21 January 2018

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Glyceryl triacetate for Canavan disease: a low-dose trial in infants and evaluation of a higher dose for toxicity in the tremor rat model

21 January 2018

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Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.

21 January 2018

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Regulation of autophagy by cytosolic acetyl-coenzyme A.

21 January 2018

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Lysine-specific modifications of p53: a matter of life and death?

21 January 2018

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Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release

21 January 2018

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Sirtuins, metabolism, and cancer

21 January 2018

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Acetate is a bioenergetic substrate for human glioblastoma and brain metastases

21 January 2018

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Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain

21 January 2018

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The effect of statins on cancer cells--review

21 January 2018

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Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

21 January 2018

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N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation

21 January 2018

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N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology

21 January 2018

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Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports

21 January 2018

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Acetyl coenzyme A: a central metabolite and second messenger

21 January 2018

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Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer

21 January 2018

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Metabolism, compartmentation, transport and production of acetate in the cortical brain tissue slice.

21 January 2018

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Acetate supplementation attenuates lipopolysaccharide-induced neuroinflammation

21 January 2018

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Dietary nonprotein calories and cerebral infarction size in rats

21 January 2018

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Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.

21 January 2018

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Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial

21 January 2018

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Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

21 January 2018

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A safety trial of high dose glyceryl triacetate for Canavan disease

21 January 2018

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Metabolic therapy: a new paradigm for managing malignant brain cancer

21 January 2018

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Metabolic management of brain cancer

21 January 2018

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Role of glucose and ketone bodies in the metabolic control of experimental brain cancer

21 January 2018

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Cancer as a metabolic disease

21 January 2018

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Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor

21 January 2018

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Nonhistone protein acetylation as cancer therapy targets

21 January 2018

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Acetate supplementation modulates brain adenosine metabolizing enzymes and adenosine A₂A receptor levels in rats subjected to neuroinflammation

21 January 2018

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Acetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of neuroinflammation

21 January 2018

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The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma

21 January 2018

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Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma.

21 January 2018

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Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome

21 January 2018

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ATP-citrate lyase links cellular metabolism to histone acetylation

21 January 2018

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New and emerging HDAC inhibitors for cancer treatment

21 January 2018

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The Ketogenic Diet Alters the Hypoxic Response and Affects Expression of Proteins Associated with Angiogenesis, Invasive Potential and Vascular Permeability in a Mouse Glioma Model

21 January 2018

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The ketogenic diet for the treatment of malignant glioma

21 January 2018

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An acetate switch regulates stress erythropoiesis

21 January 2018

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Production of acetate in the liver and its utilization in peripheral tissues

21 January 2018

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Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism

21 January 2018

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Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase: implications for the mechanism of acetate PET.

21 January 2018

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The importance of acetyl coenzyme A synthetase for 11C-acetate uptake and cell survival in hepatocellular carcinoma.

21 January 2018

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Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer

21 January 2018

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Regulation of cellular metabolism by protein lysine acetylation

21 January 2018

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ATP citrate lyase inhibitors as novel cancer therapeutic agents

21 January 2018

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Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report

21 January 2018

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Structures of N-terminally acetylated proteins

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.25305

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4 September 2017

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