Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment (Q38246724)

1 September 2017

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title

Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment (English)

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1 September 2017

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Dmitry I. Gabrilovich

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object named as

Dmitry I Gabrilovich

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1 September 2017

Vinit Kumar

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1 September 2017

publication date

1 December 2014

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1 September 2017

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1 September 2017

volume

143

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1 September 2017

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1 September 2017

page(s)

512-519

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Hypoxia-inducible factors as key regulators of tumor inflammation

1 September 2017

cites work

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Hypoxia and gastrointestinal disease

21 January 2018

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Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

21 January 2018

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Targeting the HIF pathway in inflammation and immunity

21 January 2018

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RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization

21 January 2018

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The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism

21 January 2018

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Molecular pathways: hypoxia response in immune cells fighting or promoting cancer

21 January 2018

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The cellular and molecular origin of tumor-associated macrophages

21 January 2018

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Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.

21 January 2018

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Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

21 January 2018

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HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

21 January 2018

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Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors

21 January 2018

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Macrophage polarization in tumour progression

21 January 2018

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Macrophage activation and polarization

21 January 2018

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Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses

21 January 2018

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Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis

21 January 2018

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A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).

21 January 2018

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Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages

21 January 2018

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

21 January 2018

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Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

21 January 2018

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Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model

21 January 2018

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Hypoxia-inducible factor-2α regulates GM-CSF-derived soluble vascular endothelial growth factor receptor 1 production from macrophages and inhibits tumor growth and angiogenesis

21 January 2018

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Monocyte-derived macrophages matured under prolonged hypoxia transcriptionally up-regulate HIF-1α mRNA.

21 January 2018

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Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology

21 January 2018

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Overexpression of cyclooxygenase-2 in urothelial carcinoma in conjunction with tumor-associated-macrophage infiltration, hypoxia-inducible factor-1alpha expression, and tumor angiogenesis

21 January 2018

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Origin and development of dendritic cells

21 January 2018

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Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow.

21 January 2018

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Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo

21 January 2018

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The CD8+ dendritic cell subset

21 January 2018

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Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function

21 January 2018

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HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination

21 January 2018

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Oxygen is a master regulator of the immunogenicity of primary human glioma cells

21 January 2018

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Short-term hypoxia enhances the migratory capability of dendritic cell through HIF-1α and PI3K/Akt pathway

21 January 2018

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Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration

21 January 2018

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Coordinated regulation of myeloid cells by tumours

21 January 2018

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Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF.

21 January 2018

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Subsets of myeloid-derived suppressor cells in tumor-bearing mice

21 January 2018

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Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

21 January 2018

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Myeloid derived suppressor cells in human diseases

21 January 2018

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Reversal of myeloid cell-mediated immunosuppression in patients with metastatic renal cell carcinoma

21 January 2018

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Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy

21 January 2018

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A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells.

21 January 2018

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Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells

21 January 2018

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Immunosuppressive CD14+HLA-DRlow/- monocytes in prostate cancer

21 January 2018

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A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells

21 January 2018

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IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients.

21 January 2018

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Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

21 January 2018

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HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

21 January 2018

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SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1α-dependent glycolysis

21 January 2018

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PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

21 January 2018

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Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction

21 January 2018

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Culturing at atmospheric oxygen levels impacts lymphocyte function

21 January 2018

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Importance of culturing primary lymphocytes at physiological oxygen levels

21 January 2018

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Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction.

21 January 2018

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Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival

21 January 2018

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The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis.

21 January 2018

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Hypoxia-dependent inhibition of tumor cell susceptibility to CTL-mediated lysis involves NANOG induction in target cells

21 January 2018

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Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues

21 January 2018

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Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium

21 January 2018

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Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia

21 January 2018

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A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells

21 January 2018

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Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

21 January 2018

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Overexpression of hypoxia-inducible factor 1 alpha impacts FoxP3 levels in mycosis fungoides--cutaneous T-cell lymphoma: clinical implications.

21 January 2018

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Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.

21 January 2018

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HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253499

Significance of blood vessel leakiness in cancer.

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253499

Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253499

Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253499

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253499

Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas.

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253499

Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies.

5 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253499

The number of regulatory T cells in prostate cancer is associated with the androgen receptor and hypoxia-inducible factor (HIF)-2α but not HIF-1α

5 November 2018

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Prognostic significance of HIF-2alpha expression on tumor infiltrating macrophages in patients with uterine cervical cancer undergoing radiotherapy

21 January 2018

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12 December 2020

Hypoxia-inducible factor-1alpha expression correlates with focal macrophage infiltration, angiogenesis and unfavourable prognosis in urothelial carcinoma

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12 December 2020

Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes

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12 December 2020

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo

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12 December 2020

SnapShot: Dendritic Cells

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12 December 2020

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

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12 December 2020

Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression

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12 December 2020

A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

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12 December 2020

Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes

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12 December 2020

Identification of a New Subset of Myeloid Suppressor Cells in Peripheral Blood of Melanoma Patients With Modulation by a Granulocyte-Macrophage Colony-Stimulation Factor–Based Antitumor Vaccine

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12 December 2020

Identifiers

DOI

10.1111/IMM.12380

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1 September 2017

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