Immunological dysregulation in multiple myeloma microenvironment. (Q38228353)

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Immunological dysregulation in multiple myeloma microenvironment (English)

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tumor microenvironment

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Francesco Di Raimondo

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9 March 2020

1 reference

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Concetta Conticello

1 reference

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Alessia La Fauci

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Nunziatina Laura Parrinello

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11 June 2014

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BioMed Research International

9 references

22 March 2019

3 April 2019

17 June 2019

30 June 2019

25 June 2019

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2014

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page(s)

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells

6 September 2017

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Multiple myeloma bone marrow niche

6 September 2017

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Myeloid-derived suppressor cells: linking inflammation and cancer

6 September 2017

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CD200 expression may help in differential diagnosis between mantle cell lymphoma and B-cell chronic lymphocytic leukemia.

6 September 2017

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Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study

6 September 2017

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Regulatory T cells and multiple myeloma

6 September 2017

1 reference

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Bone marrow microenvironment and the identification of new targets for myeloma therapy

6 September 2017

1 reference

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Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma

6 September 2017

1 reference

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Multiple myeloma: new staging systems for diagnosis, prognosis and response evaluation.

6 September 2017

1 reference

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The malignant clone and the bone-marrow environment

6 September 2017

1 reference

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Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma

6 September 2017

1 reference

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Mouse models of human myeloma

6 September 2017

1 reference

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Immunodeficiency and immunotherapy in multiple myeloma

6 September 2017

1 reference

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Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis

6 September 2017

1 reference

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Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

6 September 2017

1 reference

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Tumor microenvironment and drug resistance in hematologic malignancies

6 September 2017

1 reference

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Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression

6 September 2017

1 reference

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Cytokines and signal transduction

6 September 2017

1 reference

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BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone

6 September 2017

1 reference

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Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model

6 September 2017

1 reference

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Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications

6 September 2017

1 reference

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NF-kappa B as a therapeutic target in multiple myeloma

6 September 2017

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IL-6 transgenic mouse model for extraosseous plasmacytoma

6 September 2017

1 reference

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Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRij mouse

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

The 5T2 mouse multiple myeloma model: characterization of 5T2 cells within the bone marrow

6 September 2017

1 reference

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A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

6 September 2017

1 reference

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NF-κB localization in multiple myeloma plasma cells and mesenchymal cells.

6 September 2017

1 reference

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Diagnostic usefulness and prognostic impact of CD200 expression in lymphoid malignancies and plasma cell myeloma

14 September 2017

1 reference

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Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

CD200 is a new prognostic factor in multiple myeloma

14 September 2017

1 reference

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LAGlambda-1: a clinically relevant drug resistant human multiple myeloma tumor murine model that enables rapid evaluation of treatments for multiple myeloma

14 September 2017

1 reference

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A clinically relevant SCID-hu in vivo model of human multiple myeloma

14 September 2017

1 reference

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Prompt tumor formation and maintenance of constitutive NF-kappaB activity of multiple myeloma cells in NOD/SCID/gammacnull mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Establishment of a new model of human multiple myeloma using NOD/SCID/gammac(null) (NOG) mice

14 September 2017

1 reference

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Targeting immune suppression with PDE5 inhibition in end-stage multiple myeloma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

The role of tumor expression of CD200 in tumor formation, metastasis and susceptibility to T lymphocyte adoptive transfer therapy

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Under one roof: The bone marrow survival niche for multiple myeloma and normal plasma cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

A unique three-dimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Dysfunctional T regulatory cells in multiple myeloma

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Long-term follow-up of MRC Myeloma IX trial: Survival outcomes with bisphosphonate and thalidomide treatment.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Myeloma skews regulatory T and pro-inflammatory T helper 17 cell balance in favor of a suppressive state

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Immunosuppressive CD14+HLA-DR(low)/- monocytes in B-cell non-Hodgkin lymphoma

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Increased regulatory versus effector T cell development is associated with thymus atrophy in mouse models of multiple myeloma.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Prognostic value of bone marrow angiogenesis in patients with multiple myeloma undergoing high-dose therapy.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Viral antigen-specific CD8+ T-cell responses are impaired in multiple myeloma

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

CD4+CD25+FoxP3+regulatory T cells are increased whilst CD3+CD4−CD8−αβTCR+Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4071780

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma

1 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2014%2F198539

Increased Level of both CD4+FOXP3+ Regulatory T Cells and CD14+HLA-DR−/low Myeloid-Derived Suppressor Cells and Decreased Level of Dendritic Cells in Patients with Multiple Myeloma

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2014%2F198539

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2014%2F198539

The leukocyte/neuron cell surface antigen OX2 binds to a ligand on macrophages

21 January 2018

1 reference

12 December 2020

Angiogenic factors in multiple myeloma: higher levels in bone marrow than in peripheral blood

1 reference

12 December 2020

Hyperdiploidy is a common finding in monoclonal gammopathy of undetermined significance and monosomy 13 is restricted to these hyperdiploid patients

1 reference

12 December 2020

Increased numbers of T helper 17 cells and the correlation with clinicopathological characteristics in multiple myeloma

1 reference

12 December 2020

Primary myeloma cells growing in SCID-hu mice: a model for studying the biology and treatment of myeloma and its manifestations

1 reference

12 December 2020

Multiple myeloma induces the immunosuppressive capacity of distinct myeloid-derived suppressor cell subpopulations in the bone marrow

1 reference

12 December 2020

Induction of immunosuppressive functions of dendritic cells in vivo by CD4+CD25+ regulatory T cells: role of B7-H3 expression and antigen presentation

1 reference

12 December 2020

Dysregulation in T helper 1/T helper 2 cytokine ratios in patients with multiple myeloma

1 reference

12 December 2020

The SCID-rab model: a novel in vivo system for primary human myeloma demonstrating growth of CD138-expressing malignant cells

1 reference

12 December 2020

The proliferative potential of myeloma plasma cells manifest in the SCID-hu host

1 reference

12 December 2020

CD200 expression in plasma cell myeloma

1 reference

12 December 2020

Induction by lenalidomide and dexamethasone combination increases regulatory cells of patients with previously untreated multiple myeloma

1 reference

12 December 2020

Significantly reduced regulatory T cell population in patients with untreated multiple myeloma

1 reference

12 December 2020

Microenvironment: Neighbourhood watch

1 reference

12 December 2020

Identifiers

DOI

10.1155/2014/198539

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25013764%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25013764%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

PubMed publication ID

25013764

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25013764%20AND%20SRC:MED&resulttype=core&format=json