Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo (Q36162685)

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English	Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo	scientific article

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28 January 2020

Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo (English)

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28 January 2020

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28 January 2020

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Sun-Young Kong

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28 January 2020

Mariateresa Fulciniti

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28 January 2020

Xianfeng Li

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28 January 2020

Weihua Song

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28 January 2020

Sabikun Nahar

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28 January 2020

Peter Burger

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28 January 2020

Mathew J Rumizen

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28 January 2020

Klaus Podar

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28 January 2020

Dharminder Chauhan

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28 January 2020

Teru Hideshima

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28 January 2020

Nikhil C Munshi

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28 January 2020

Paul Richardson

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28 January 2020

Ann Clark

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28 January 2020

Janet Ogden

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28 January 2020

Andreas Goutopoulos

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28 January 2020

Luca Rastelli

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28 January 2020

Kenneth C Anderson

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28 January 2020

Yu-Tzu Tai

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28 January 2020

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12 March 2010

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28 January 2020

British Journal of Haematology

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28 January 2020

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28 January 2020

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28 January 2020

537-549

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28 January 2020

Safety and efficacy of single-agent lenalidomide in patients with relapsed and refractory multiple myeloma

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2 October 2017

CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells

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2 October 2017

Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation

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2 October 2017

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CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

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2 October 2017

Clinical and biological significance of RAS mutations in multiple myeloma.

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2 October 2017

Therapeutic strategies for targeting BRAF in human cancer

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Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

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2 October 2017

Advances in targeting the Ras/Raf/MEK/Erk mitogen-activated protein kinase cascade with MEK inhibitors for cancer therapy

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2 October 2017

Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu

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Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

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2 October 2017

Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis

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2 October 2017

Relevance of Ras gene mutations in the context of the molecular heterogeneity of multiple myeloma.

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2 October 2017

Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance.

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2 October 2017

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

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2 October 2017

BRAF mutation predicts sensitivity to MEK inhibition

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2 October 2017

Human anti-CD40 antagonist antibody triggers significant antitumor activity against human multiple myeloma

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2 October 2017

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2 October 2017

Possible roles for activating RAS mutations in the MGUS to MM transition and in the intramedullary to extramedullary transition in some plasma cell tumors

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2 October 2017

Advances in biology of multiple myeloma: clinical applications

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2 October 2017

Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications

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2 October 2017

Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma

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2 October 2017

Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.

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2 October 2017

Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.

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2 October 2017

Downstream effectors of oncogenic ras in multiple myeloma cells

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Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation

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Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6.

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Activating Ras mutations in patients with plasma-cell disorders: a reappraisal

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12 December 2020

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BRAF gene is not mutated in plasma cell leukemia and multiple myeloma

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https://pubmed.ncbi.nlm.nih.gov/20331454

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias

1 reference

https://pubmed.ncbi.nlm.nih.gov/20331454

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/20331454

12 December 2020

based on heuristic

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10.1111/J.1365-2141.2010.08127.X

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28 January 2020

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28 January 2020

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28 January 2020

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